Clindamycin Flashcards
1
Q
chemical
A
lincosamide
2
Q
structure
A
Lincomycin (X)
Clindamycin
3
Q
spectrum of activity
A
G+ve/G-ve bacteria
penicillinase staph
bacteriodes
prevotella
4
Q
mechanism of action
A
inhibits protein synthesis
5
Q
pharmokinetics
A
oral absorption - 90%, half life - 3 hours, peak serum - 2.5 ugml
6
Q
unwanted effects
A
nausea, vomitting, oesophagitis, glossitis, stomatitis, metalic taste, maculopapular rash
7
Q
Interactions
A
non-depolarising neuromuscular blocking agents, absorption slowed by some anti-diarrhoea drugs, antagonism with erythromycin
8
Q
indications
A
second line
penicillin allergy
9
Q
dose/ duration/ frequency and route
A
150-300mg, 6 hourly, 3-5 days and oral route
10
Q
A
