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MSK 2 Post Midterm > Papulosquamous Diseases 1 and 2 > Flashcards

Papulosquamous Diseases 1 and 2 Flashcards

1
Q

Define papulosquamous

A

Morphologic dermatologic condition consisting of mainly papules and scale (squamous)

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2
Q

SCALY WHITE PLAQUES OVER ELBOWS AND KNEEES. A chronic inflammatory scaling eruption. HLA-B13, AD.

A

Psoriasis vulgaris

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3
Q

Branny, greasy red scales on face/chest/penis. Mild flaking in hair baring areas (“dandruff skin”).

A

Seborrheic dermatitis

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4
Q

Pathogenesis of sborrheic dermatitis.

A

Abnormal immune response to P. OVALE (with normal amt of yeast), resulting in free fatty acid release.

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5
Q

Chronic infection, DM patients, red/brown scaly macules with an erosive collarette-like scale in warm/moist areas (toes, groin, axilla).

A

Erythrasma

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6
Q

Describe visualization test of erythasma.

Describe pathogenesis (G+ rod, normal skin flora)

A

Wood’s Lamp

Corynebacterium minutissimum.

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7
Q

Wickham’s stria. Painful/burning at wrists/nails/oral cavity/genatalia. Sawtooth Band like infiltrate at DEJ. M=F, 30-60 years.

What is this?

What is the pathognomonic description?

What virus is associated with this?

A

Lichen Planus

Pruritic, Polygonal, Purple, Plaque ( greater than 1cm), Papule (less than 1cm)

Hep C

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8
Q

Rose pink colored scaly erythematous patches or thin palques. CD4+ and Langerhan’s cells in dermis.

What is this? What sex does it affect? What time of year?

A

Pityriasis rosea

Spring or fall, F>M 2:1

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9
Q

Describe the pattern of spread of of pityriasis rosea.

A

Starts at Herald Patch on person’s back. Spreads on “Christmas tree”distribution on trunk.

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10
Q

Superficial infection of the skin that results in tinea corporis.

Lab test.

A

Dermatophyte infection with trichophyton, microsporum, epidermophyton, T. rubrum.

KOH

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11
Q

Pathophysiology of dermatophyte infection.

A

Nonliving cornified skin/hair/nail. Tx the source, NOT with antifungals.

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12
Q

Reddish-orange scaling plaques of unknown etiology with palmoplantar keratoderma and follicular keratotic papules.

What is this?

Due to what deficincy?

A

Pityriasis rubra pilaris

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13
Q

Pathogenesis of pityriasis rubra pilaris

A

vitamin A deficiency. AD inheritance

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14
Q

What type of pityriasis rubra pilaris has red brown plaques with islands of sparing?

Similar type that is associated with virus?

A

type 1 - classic adult, most common

Type 6 - HIV

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15
Q

What type of pityriasis rubra pilaris has glove and stocking distribution?

A

type 2

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16
Q

What type of pityriasis rubra pilaris affects CHILDREN

A

type 3 - classic juvenile

17
Q

What type of pityriasis rubra pilaris is well demarcated follicular hyperkeratosis along elbows and knees

A

type 4 - circumscribed Juvenile

18
Q

What type of pityriasis rubra pilaris has follicular hyperkeratosis with scleroderma like palms and soles?

A

type 5 - Atypical juvenile

19
Q

treatment of pityriasis rubra pilaris

A

biopsy, then administer retinoids

20
Q

Pruritic, scaling plaques that mimic eczema. Red-brown shades or hypopigmented. Round, oval, annular or bizarre shaped cells. M>F, >50years old, LN and Organs involved.

A

Cutaneous T Cell Lymphoma

21
Q

Dx CTCL

A

biopsy, CXR, CBC with Buffy coat for SEZARY CELLS.

22
Q

Tx of CTCL

A

topical steroids, PUVA, topical nitrogen mustard.

23
Q

Scarring atrophic photosensitizing dermatosis. Results in pruritic, erythematous papule or plaque with modesl scaling. Hypo or hyper pigmented. Mucosa, palms, soles. 20-40yo/M=F.

A

Discoid Lupus Erythematosus

24
Q

Pathogenesis of Discoid Lupus Erythematosis

Chronic DLE is at risk for developing…

A

UV induced HSP

At risk for developing SCCa

25
Q

Tx of Discoid Lupus Erythematosis

A

sunscreen, topical steroids, Intralesional steroids, surgery, antimalarials

26
Q

Papulosquamous, pustular, bullous, EM-like, TEN, fixed.

How long from inciting factor (and what is the inciting factor)?

A

Drug eruption 2-3 weeks post starting drug.

27
Q

What do these cause?
Coumadin
Silver nitrate
Doxycycline

What is Jarisch-Herxheimer Reaction?

A

Coumadin - purpura
Silver nitrate - argyria (skin turns blue-grey)
Doxycycline - phototoxic

Jarisch-Herxheimer Reaction - Bug toxins released after antibiotic kills bugs

28
Q

What types of HSR:

  • urticaria
  • cytotoxic
  • cell mediated immune complex
  • delayed HS
A

Type 1-4

MSK 2 Post Midterm (11 decks)

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