Papulosquamous Diseases 1 and 2 Flashcards
Define papulosquamous
Morphologic dermatologic condition consisting of mainly papules and scale (squamous)
SCALY WHITE PLAQUES OVER ELBOWS AND KNEEES. A chronic inflammatory scaling eruption. HLA-B13, AD.
Psoriasis vulgaris
Branny, greasy red scales on face/chest/penis. Mild flaking in hair baring areas (“dandruff skin”).
Seborrheic dermatitis
Pathogenesis of sborrheic dermatitis.
Abnormal immune response to P. OVALE (with normal amt of yeast), resulting in free fatty acid release.
Chronic infection, DM patients, red/brown scaly macules with an erosive collarette-like scale in warm/moist areas (toes, groin, axilla).
Erythrasma
Describe visualization test of erythasma.
Describe pathogenesis (G+ rod, normal skin flora)
Wood’s Lamp
Corynebacterium minutissimum.
Wickham’s stria. Painful/burning at wrists/nails/oral cavity/genatalia. Sawtooth Band like infiltrate at DEJ. M=F, 30-60 years.
What is this?
What is the pathognomonic description?
What virus is associated with this?
Lichen Planus
Pruritic, Polygonal, Purple, Plaque ( greater than 1cm), Papule (less than 1cm)
Hep C
Rose pink colored scaly erythematous patches or thin palques. CD4+ and Langerhan’s cells in dermis.
What is this? What sex does it affect? What time of year?
Pityriasis rosea
Spring or fall, F>M 2:1
Describe the pattern of spread of of pityriasis rosea.
Starts at Herald Patch on person’s back. Spreads on “Christmas tree”distribution on trunk.
Superficial infection of the skin that results in tinea corporis.
Lab test.
Dermatophyte infection with trichophyton, microsporum, epidermophyton, T. rubrum.
KOH
Pathophysiology of dermatophyte infection.
Nonliving cornified skin/hair/nail. Tx the source, NOT with antifungals.
Reddish-orange scaling plaques of unknown etiology with palmoplantar keratoderma and follicular keratotic papules.
What is this?
Due to what deficincy?
Pityriasis rubra pilaris
Pathogenesis of pityriasis rubra pilaris
vitamin A deficiency. AD inheritance
What type of pityriasis rubra pilaris has red brown plaques with islands of sparing?
Similar type that is associated with virus?
type 1 - classic adult, most common
Type 6 - HIV
What type of pityriasis rubra pilaris has glove and stocking distribution?
type 2
What type of pityriasis rubra pilaris affects CHILDREN
type 3 - classic juvenile
What type of pityriasis rubra pilaris is well demarcated follicular hyperkeratosis along elbows and knees
type 4 - circumscribed Juvenile
What type of pityriasis rubra pilaris has follicular hyperkeratosis with scleroderma like palms and soles?
type 5 - Atypical juvenile
treatment of pityriasis rubra pilaris
biopsy, then administer retinoids
Pruritic, scaling plaques that mimic eczema. Red-brown shades or hypopigmented. Round, oval, annular or bizarre shaped cells. M>F, >50years old, LN and Organs involved.
Cutaneous T Cell Lymphoma
Dx CTCL
biopsy, CXR, CBC with Buffy coat for SEZARY CELLS.
Tx of CTCL
topical steroids, PUVA, topical nitrogen mustard.
Scarring atrophic photosensitizing dermatosis. Results in pruritic, erythematous papule or plaque with modesl scaling. Hypo or hyper pigmented. Mucosa, palms, soles. 20-40yo/M=F.
Discoid Lupus Erythematosus
Pathogenesis of Discoid Lupus Erythematosis
Chronic DLE is at risk for developing…
UV induced HSP
At risk for developing SCCa
Tx of Discoid Lupus Erythematosis
sunscreen, topical steroids, Intralesional steroids, surgery, antimalarials
Papulosquamous, pustular, bullous, EM-like, TEN, fixed.
How long from inciting factor (and what is the inciting factor)?
Drug eruption 2-3 weeks post starting drug.
What do these cause?
Coumadin
Silver nitrate
Doxycycline
What is Jarisch-Herxheimer Reaction?
Coumadin - purpura
Silver nitrate - argyria (skin turns blue-grey)
Doxycycline - phototoxic
Jarisch-Herxheimer Reaction - Bug toxins released after antibiotic kills bugs
What types of HSR:
- urticaria
- cytotoxic
- cell mediated immune complex
- delayed HS
Type 1-4
