Buzz Flashcards
HLA-B8/DR3
Myasthenia Gravis
HLA DR4
Rheumatoid Arthritis, Giant Cell/Temporal Arteritis
HLA-B27
seronegative SpA
HLA-B13
Psoriasis vulgaris
HLA-B1, B8, DR8, DRQ
Dermatitis Herpetiformis
HLA-B12
TEN
HLA-B51
Behcet
anti-SSa/B
Sjogren
anti-centromere
CREST
anti-histone
homogenous ANA
drug induced lupus
SHIPPE (sulfa, hydralazine, INZ, Phenytoin, Procainamide, Etanercept)
anti-Sm
SLE
anti-topoisomerase 1
anti-Scl 70
RNA-polymerase 1 and 3
diffuse scleroderma
NHLymphoma
sjogren
MALT B lymphoma
sjogren
Breast cancer
dermatomyositis
Adenocarcinoma, barrett’s esophagus
CREST
pulmonary artery aneurysm
limited scleroderma
interstitial lung disease
diffuse scleroderma
aortic aneurysm, pulseless
takayasu arteritis
pulmonary embolism (2)
behcet’s, aPL syndrome
rimmed vacuole, anti-cN1a
incusion body myositis
HepB
PAN
HepC
Lichen planus
beta2-GPI, anti cardiolipin, anti-phospholipid
antiphospholipid syndrome (aPL)
HA, vision, chewing, T3 HSR, granulomas, elevated ESR
Dz
Tx
Giant Cell/Temporal ARteritis
Tx: steroids BEFORE biopsy
Pulseless, HTN, night sweats, aortic regurg, renal artery stenosis, granulomas, copper wiring
Dz
Tx
Takayasu Arteritis
Tx: steroids
Young male, T3 HSR, HepB, livedi reticularis, no lungs, intestinal angina, mononeu. multiplex, glomerular ischemia, P-ANCA, fibrinoid necrosis.
Dz
PAN
CRASH & and Burn. young child, later in life coronary artery aneurysm
Dz
Kawasaki
CRASH = Conjuctivitis, Rash (desquam), Adenopathy (LAD), Strawberry tongue, Hand-foot edema & Burn (fever)
Male smoker, segmental, gangrene, ulcers, autoamputation, Raynauds
Dz
Buerger
Child post URI. Palpable purpura. No Thrombocytopenic Purpura. Arthralgia, abdominal pain. IgA
Dz
HSP
Lungs + kidney. Type 2 HSR, Type 4 collagen. Nephritic –> crescents. Glomerular caps, pulmonary caps.
Dz
Tx
Anti-GBM
Tx: plasmapheresis
PROSE: Pathery, Recurrent genital ulcers, ORAL ULCERS, Skin (erythema nodosum), Eye (uveitis), DVTs.
large joint arthralgia and ulcers in distal ileum or cecum (ddx CD)
Behcet Syndrome
C-ANCA. NP, lung, kidney. granulomas. Saddle nose
Wegner’s
Asthama, allergies, palpable purpura, P-ANCA, eosinophilia,
Churg Strauss
Drug induced SLE: SHIPPE
sulfa, hydralazine, INH, phenytoin, procainamide, Etanercept, (methyldopa)
Facial swelling (MALToma), dry mouth (oral candida, caries), dry eyes (keratoC sicca), contractures, Ro/SSA, La/SSB
Sjogrens
hypersens –> fibroblasts –> collagen, fibrosis.
Puffy skin, fingertip pitting and nodules. Oral/perioral red spots, perioral furrowing, silicosis (potential cause), GAVE, esophageal dysmotility (–>GERD, aspiration).
scleroderma
Young or Mid-age female, bilateral proximal muscles weakness w/o sensory sxs.
DX: Biopsy- perimysial and perivascular inflammation, *perifascicular atrophy.
heliotrope rash, shawl rash, gottron papules (extensor knuckles), Malignancy, CD4. Anti-Jo, increased CK, ANA, Mi-2
Dz
Tx
dermatomyositis
Tx: immunosuppressants
Mid-age female, bilateral proximal muscles weakness. Subacute proximal muscle weakness. NO skin changes like. Elevated serum CK, Anti-Jo-1
Muscle bx: endomysial inflammation with invasion of non-necrotic muscle fibers without features suggestive of another dx
Dz
Tx
Polymyositis
Tx: immunosuppressants
Male >40-50 yo. Finger flexion or quadriceps weakness
Muscle bx: endomysial inflammation, rimmed vacuoles, invasion of non-necrotic muscle fibers, anti-cN1A autoantibodies.
Dz
Tx
Inclusion body myositis
Tx: supportive
Palpable purpura
HSP, CS
granulomas
giant cell, takayasu, wegner
Associated with GCA Proximal severe, symmetrical morning and daylong stiffness, soreness and pain in shoulder, neck and pelvic girdles Feelings of weakness a result of pain (as opposed to PM) ***No inflammation on muscle bx** Muscle enzymes and EMG normal Elevated ESR and CRP
Polymalgia Rheumatica
Gq1b and GT1a ab; ophthalmoplegia, ataxia, arreflexia
miller fisher
anti GM1
multifocal motor neuropathy
Hu antibody
carcinomatous sensory neuropathy