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MSK 2 Post Midterm > Buzz > Flashcards

Buzz Flashcards

1
Q

HLA-B8/DR3

A

Myasthenia Gravis

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2
Q

HLA DR4

A

Rheumatoid Arthritis, Giant Cell/Temporal Arteritis

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3
Q

HLA-B27

A

seronegative SpA

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4
Q

HLA-B13

A

Psoriasis vulgaris

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5
Q

HLA-B1, B8, DR8, DRQ

A

Dermatitis Herpetiformis

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6
Q

HLA-B12

A

TEN

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7
Q

HLA-B51

A

Behcet

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8
Q

anti-SSa/B

A

Sjogren

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9
Q

anti-centromere

A

CREST

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10
Q

anti-histone

homogenous ANA

A

drug induced lupus

SHIPPE (sulfa, hydralazine, INZ, Phenytoin, Procainamide, Etanercept)

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11
Q

anti-Sm

A

SLE

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12
Q

anti-topoisomerase 1
anti-Scl 70
RNA-polymerase 1 and 3

A

diffuse scleroderma

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13
Q

NHLymphoma

A

sjogren

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14
Q

MALT B lymphoma

A

sjogren

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15
Q

Breast cancer

A

dermatomyositis

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16
Q

Adenocarcinoma, barrett’s esophagus

A

CREST

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17
Q

pulmonary artery aneurysm

A

limited scleroderma

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18
Q

interstitial lung disease

A

diffuse scleroderma

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19
Q

aortic aneurysm, pulseless

A

takayasu arteritis

20
Q

pulmonary embolism (2)

A

behcet’s, aPL syndrome

21
Q

rimmed vacuole, anti-cN1a

A

incusion body myositis

22
Q

HepB

A

PAN

23
Q

HepC

A

Lichen planus

24
Q

beta2-GPI, anti cardiolipin, anti-phospholipid

A

antiphospholipid syndrome (aPL)

25
Q

HA, vision, chewing, T3 HSR, granulomas, elevated ESR
Dz
Tx

A

Giant Cell/Temporal ARteritis

Tx: steroids BEFORE biopsy

26
Q

Pulseless, HTN, night sweats, aortic regurg, renal artery stenosis, granulomas, copper wiring
Dz
Tx

A

Takayasu Arteritis

Tx: steroids

27
Q

Young male, T3 HSR, HepB, livedi reticularis, no lungs, intestinal angina, mononeu. multiplex, glomerular ischemia, P-ANCA, fibrinoid necrosis.

Dz

A

PAN

28
Q

CRASH & and Burn. young child, later in life coronary artery aneurysm

Dz

A

Kawasaki

CRASH = Conjuctivitis, Rash (desquam), Adenopathy (LAD), Strawberry tongue, Hand-foot edema & Burn (fever)

29
Q

Male smoker, segmental, gangrene, ulcers, autoamputation, Raynauds
Dz

A

Buerger

30
Q

Child post URI. Palpable purpura. No Thrombocytopenic Purpura. Arthralgia, abdominal pain. IgA

Dz

A

HSP

31
Q

Lungs + kidney. Type 2 HSR, Type 4 collagen. Nephritic –> crescents. Glomerular caps, pulmonary caps.

Dz
Tx

A

Anti-GBM

Tx: plasmapheresis

32
Q

PROSE: Pathery, Recurrent genital ulcers, ORAL ULCERS, Skin (erythema nodosum), Eye (uveitis), DVTs.
large joint arthralgia and ulcers in distal ileum or cecum (ddx CD)

A

Behcet Syndrome

33
Q

C-ANCA. NP, lung, kidney. granulomas. Saddle nose

A

Wegner’s

34
Q

Asthama, allergies, palpable purpura, P-ANCA, eosinophilia,

A

Churg Strauss

35
Q

Drug induced SLE: SHIPPE

A

sulfa, hydralazine, INH, phenytoin, procainamide, Etanercept, (methyldopa)

36
Q

Facial swelling (MALToma), dry mouth (oral candida, caries), dry eyes (keratoC sicca), contractures, Ro/SSA, La/SSB

A

Sjogrens

37
Q

hypersens –> fibroblasts –> collagen, fibrosis.
Puffy skin, fingertip pitting and nodules. Oral/perioral red spots, perioral furrowing, silicosis (potential cause), GAVE, esophageal dysmotility (–>GERD, aspiration).

A

scleroderma

38
Q

Young or Mid-age female, bilateral proximal muscles weakness w/o sensory sxs.

DX: Biopsy- perimysial and perivascular inflammation, *perifascicular atrophy.

heliotrope rash, shawl rash, gottron papules (extensor knuckles), Malignancy, CD4. Anti-Jo, increased CK, ANA, Mi-2

Dz
Tx

A

dermatomyositis

Tx: immunosuppressants

39
Q

Mid-age female, bilateral proximal muscles weakness. Subacute proximal muscle weakness. NO skin changes like. Elevated serum CK, Anti-Jo-1
Muscle bx: endomysial inflammation with invasion of non-necrotic muscle fibers without features suggestive of another dx

Dz
Tx

A

Polymyositis

Tx: immunosuppressants

40
Q

Male >40-50 yo. Finger flexion or quadriceps weakness
Muscle bx: endomysial inflammation, rimmed vacuoles, invasion of non-necrotic muscle fibers, anti-cN1A autoantibodies.

Dz
Tx

A

Inclusion body myositis

Tx: supportive

41
Q

Palpable purpura

A

HSP, CS

42
Q

granulomas

A

giant cell, takayasu, wegner

43
Q 
Associated with GCA
 Proximal severe, symmetrical morning and
daylong stiffness, soreness and pain in
shoulder, neck and pelvic girdles
 Feelings of weakness a result of pain (as
opposed to PM)
 ***No inflammation on muscle bx**
 Muscle enzymes and EMG normal
 Elevated ESR and CRP
A

Polymalgia Rheumatica

44
Q

Gq1b and GT1a ab; ophthalmoplegia, ataxia, arreflexia

A

miller fisher

45
Q

anti GM1

A

multifocal motor neuropathy

46
Q

Hu antibody

A

carcinomatous sensory neuropathy

MSK 2 Post Midterm (11 decks)

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