Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MSK 2 Post Midterm > Lab Testing in Rheumatic Diseases > Flashcards

Lab Testing in Rheumatic Diseases Flashcards

1
Q

Polymyalgia rheumatica and Giant Cell Arteritis can both be monitored using __

A

ESR (acute phase reactant)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Where is CRP synthesized and what can increase it? Greater than __mg/l is considered inflammatory?

A
  • synthesized in liver and can be increased by proinflammatory cytokines
  • greater than 8mg/l is inflammatory
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What Acute Phase Reactant increases with age and is higher in F>M

A

ESR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Does ESR or CRP rise/fall more rapidly?

A

CRP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is produced by B cells in synovial joints in rheumatoid arthritis patients? This autoantibody targets ____.

A

Rheumatoid Factor. Tagets Fc portion of IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

RF is present in ___% of RA pts.

RF is present in ___% of “nodular” RA pts.

A

70-80%

100%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Cutoff valve for positive RF in:

  • ELISA
  • latex fixation
A
  • ELISA: RF > 45IU/ml

- latex fixation: RF > 1:80

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What two tests have 99.5% specificity for RA?

A

Anti CCP and positive RF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

homogenous pattern ANA - caused by?

A

drug induced lupus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

postive ANA can occur in what four types of pts?

A

normal (20-30%), RA, CTD (connective tissue disease?), malignancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Rim pattern ANA indicates…

A

anti DS DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Speckled anti SSA/B ANA indicates…

A

Sjögren syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Anticentromere antibody indicates…

A

scleroderma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Criteria for SLE

A

SOAP MD BRAIN

  • Serositis (inflammation in synovial fluid)
  • Oral ulcers
  • Arthritis
  • Photosensitivity

-Malar rash, Discoid rash

  • Blood - all low (anemia, thrombo/leukopenia)
  • Renal
  • ANA
  • Immunologic (DS DNA)
  • Neurologic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

***Define hematologic manifestations of SLE

A

– Hemolytic anemia with reticulocytosis OR

  • lymphopenia less than 1500
  • leukopenia less than 4,000
  • thrombocytopenia less than 100,000
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Antistreptolysin O antibody (ASO titer) and anti DNAase B titers indicate evidence of preceding ___ infection.

A

evidence of preceding group A streptococcal infection

Acute Rheumatic Fever; polyarticular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

strep often affects what parts of the body?

A 
large joints (asymmetric)
Post-strep Reactive Arthritis effects SMALL joints SYMMETRICALLY
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

These tests indicate ___:

CBC indicating hemolytic anemia, leukopenia and false positive RPR (reactive plasma reagin - syphilis)

A

SLE

19
Q

These tests indicate ___:

Positive anti‐CCP, elevated ESR and elevated rheumatoid factor level

A

Rheumatoid arthritis

20
Q

alcohol promotes increased ___ production and decreased excretion

A

urate

21
Q

attacks MTP, has tophi

A

gout

22
Q

tx of acute gout (3)

A

NSAIDs, colchicene, steroids

23
Q

tx of chronic gout (2)

A

XO inhibitors, Probencid (increased renal excretion)

24
Q

What imaging study of rheumatic disease has:
– Poor visualization of soft tissue
– (RA) symmetrical involvement of MCP, periarticular
osteopenia, EROSIONS in late disease

A

radiography - digital radiographs have high spatial resolution

– Plane radiographs may not detect early arthritic disease

25
Q

What imaging study of rheumatic disease:
– Aid in injecting/aspirating joint
– No radiation
– sensitive for SOFT TISSUE abnormalities (SYNOVITIS, TENDONITIS, BURSITIS) and erosions

A

Ultrasonography

26
Q

What imaging study of rheumatic disease:
– is useful for soft tissue abnormalities; good for spine, SI, synovitis, tenosynovitis, erosions
– Gadolinium contrast taken up in inflamed synovium (thickened pannus) IV gadolinium can cause nephrogenic systemic fibrosis (NSF) in patient with kidney disease

A

MRI

**GADOLINIUM TOXICITY - use CT if you can

27
Q

What imaging study of rheumatic disease is best forBONY ABNORMALITIES (trabecular, cortical bone), erosions, fractures, degenerative or inflammatory arthritis

A

CT

28
Q 
Number of Joints Involved
•Mono‐ 
•Oligo‐ 
•Pauci‐ 
•Poly‐
A
  • Mono‐ arthritis
  • Oligo‐ 3 or more
  • Pauci‐ 5 or more
  • Poly‐ more than 6
29
Q

**What rheumatic disease affects MCPs and PIPs?

A

Rheumatoid arthritis

30
Q

**What rheumatic disease affects knees, DIP, cervical and lumbar?

A

Osteoarthritis

31
Q

Three types of swelling.

A

bony, effusion, soft tissue

32
Q

define types of effusion swelling

A

synovial fluid (infl/non-inflam), pus, blood

33
Q

swan neck:
looks like ___
indicates ___

A

hyperextension of PIP

advanced RA deformity

34
Q

boutonniere:
looks like ___
indicates ___

A

hyperF of PIP

advanced RA deformity

35
Q

name 5 arthritic syndromes

A 
Syndromes
•Arthritis‐ Dermatitis
•Arthritis‐ Bowel
•Arthritis‐ Pulmonary
•Arthritis‐ Endocrine
•Arthritis‐ Ophthalmologic
36
Q

name causes of inflammatory bowel disease and Reactive arthritis that can cause arthritis

A
  • Inflammatory Bowel Disease - Ulcerative Colitis, Crohn’s Diseasem Behcet’s
  • Reactive Arthritis - Bowel Infection
37
Q

**4 bowel infections that can cause reactive arthritis

A

Salmonella, shigella, campylobacter, Yersinia (N. gono/Chlamydia)

38
Q

Name two endocrine disorders that can result in respective arthrtities

A
  1. Thyroid - carpal/tarasal tunnel syndrome

2. Diabetes - charcot’s and cheiroarthropathy (thiickened hand/skin that mimics scleroderma)

39
Q

cytoid bodies and vasculitis result in…

A

retinopathy (arthritis-ophthalmologic)

40
Q

dactylitis indicates

A

reactive arthritis

41
Q

Sjogrens, SLE, and healthy, >60 years old - all can have false positive ___?

A

RF

42
Q

Anti-CCP has greater specificity or sensitivity than RF?

A

specificity

43
Q

Joint aspiration: 200-2,000 = ?; 2000-50,000 = ?; 50,000+ = ?

A 
200-2,000 = noninflammatory
2000-50,000 = inflammatory (cloudy)
50,000+ = septic (cloudy, opaque)
44
Q

causes of drug induced lupus

A

phenytoin, hydralazine

MSK 2 Post Midterm (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions