Papillon Lefevre syndrome

Question 1

inherited AD
presents w
palmoplantar keratoderma and destructive periodontitis usually beginning in young childhood. well demarcated, erythematous, hyperkeratotic lesions on palms and soles may extend to dorsal hands and feet. hyperkeratosis may also be present in elsbows knees and achilles tendon. transverge grooves of nails. severe gingival inflammation w loss of alveolar bone is typical.

Answer 1

Papillon Lefevre syndrome

Question 2

histo

Answer 2

psoriasiform pattern.

Question 3

mutation

Answer 3

gene for Cathepsin C.

Question 4

early onset of periodontal disease may be attributed to

Answer 4

alterations in polymorphonuclear leukocyte func caused by actinomyces actinomycetemcomitans