Pantothenic Acid Flashcards
Pantothenic Acid is shown to have a relationship with (list 4)
- Inositol
- Thiamin
- Biotin
- Vitamin B6
The Greek derivation of Pantothenic acid means
from everywhere
Pantothenic Acid was identified as one of the components of what molecule?
Coenzyme A (CoA)
What is hydrolyzed in the lumen releasing pantothenic acid?
Dietary CoA
Pantothenic acid can be absorbed via …
Passive diffusion
*Although the majority is absorbed via saturable, sodium-dependent active transport.
Once absorbed into the bloodstream pantothenic acid is transported mainly via ____, it also can be free in plasma.
RBCs
- Injection of pantothenate shows it is rapidly uptaken by red blood cells and other tissues.
40% of radio labeled pantothenate ends up where?
in muscle tissue
What is CoA broken down to and excreted as in the urine?
Free pantothenic acid
List the 4 main functions of pantothenic acid.
- Forms the CoA portion of Acetyl-CoA, which has a functional role in TCA (Krebs Cycle) and Beta Oxidation.
- Required for synthesis of:
- Sphingolipids
- Leucine
- Arginine
- Methionine
- Isoprenoid derivatives: Farnesol, Cholesterol, Steroid hormones, Vit. A & Vit. D - CoA provides the acetyl group to acetylcholine.
- Serotonin -> Melatonin
What are the food sources of pantothenic acid?
Everywhere
Beef, chicken, liver, eggs, tomatoes, cashews, broccoli, potatoes, whole grains, fortified foods, & baby foods.
What is the result of pantothenic acid toxicity?
No known adverse effects with overconsumption.
- IOM did not set a tolerable upper limit for this vitamin.
What group of people have higher urinary excretion of pantothenic acid than healthy persons?
Diabetics
Low blood concentrations of pantothenic acid have been reported in patients with?
Rheumatoid arthritis
