Pancytopenia and bone marrow failure Flashcards
what is pancytopenia
reduction in all cell lines
what is pancytopenia
reduction in all cell lines
causes of pancytopenia
decr marrow production- aplastic anaemia, infiltration- acute leukaemia, myelodysplasia, myeloma, lymphoma, TB; megaloblastic anaemia, myelofibrosis. incr peripheral destruction- hypersplenism
agranulocytosis
decr white cells- increased susceptbility to infection
aplastic anaemia
pancytopenia and hypoplastic marrow- marrow stops making cells.
what does aplastic anaemia present with
features of anaemia, infection, bleeding
causes aplastic anaemia
autoimmune, drugs, irradiation, inherited- Fanconi
treatment aplastic anaemia
support bone marrow. bone marrow transplant from HLA matched sibling. immunosuppression
when are platelets indicated
when are platelets indicated
causes of pancytopenia
decr marrow production- aplastic anaemia, infiltration- acute leukaemia, myelodysplasia, myeloma, lymphoma, TB; megaloblastic anaemia, myelofibrosis. incr peripheral destruction- hypersplenism
agranulocytosis
decr white cells- increased susceptbility to infection
aplastic anaemia
pancytopenia and hypoplastic marrow- marrow stops making cells.
what does aplastic anaemia present with
features of anaemia, infection, bleeding
causes aplastic anaemia
autoimmune, drugs, irradiation, inherited- Fanconi
treatment aplastic anaemia
support bone marrow. bone marrow transplant from HLA matched sibling. immunosuppression
what occurs in marrow support
red cell transfusion, platelets, neutrophils
when are platelets indicated
what is the aspirate for
provides a film
what is the trephine for
core of bone allows assessment bone marrow cellularity, architecture, presence infiltrative disease
