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Haematology > Pancytopenia and bone marrow failure > Flashcards

Pancytopenia and bone marrow failure Flashcards

1
Q

what is pancytopenia

A

reduction in all cell lines

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2
Q

what is pancytopenia

A

reduction in all cell lines

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3
Q

causes of pancytopenia

A

decr marrow production- aplastic anaemia, infiltration- acute leukaemia, myelodysplasia, myeloma, lymphoma, TB; megaloblastic anaemia, myelofibrosis. incr peripheral destruction- hypersplenism

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4
Q

agranulocytosis

A

decr white cells- increased susceptbility to infection

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5
Q

aplastic anaemia

A

pancytopenia and hypoplastic marrow- marrow stops making cells.

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6
Q

what does aplastic anaemia present with

A

features of anaemia, infection, bleeding

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7
Q

causes aplastic anaemia

A

autoimmune, drugs, irradiation, inherited- Fanconi

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8
Q

treatment aplastic anaemia

A

support bone marrow. bone marrow transplant from HLA matched sibling. immunosuppression

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9
Q

when are platelets indicated

A
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10
Q

when are platelets indicated

A
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11
Q

causes of pancytopenia

A

decr marrow production- aplastic anaemia, infiltration- acute leukaemia, myelodysplasia, myeloma, lymphoma, TB; megaloblastic anaemia, myelofibrosis. incr peripheral destruction- hypersplenism

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12
Q

agranulocytosis

A

decr white cells- increased susceptbility to infection

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13
Q

aplastic anaemia

A

pancytopenia and hypoplastic marrow- marrow stops making cells.

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14
Q

what does aplastic anaemia present with

A

features of anaemia, infection, bleeding

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15
Q

causes aplastic anaemia

A

autoimmune, drugs, irradiation, inherited- Fanconi

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16
Q

treatment aplastic anaemia

A

support bone marrow. bone marrow transplant from HLA matched sibling. immunosuppression

17
Q

what occurs in marrow support

A

red cell transfusion, platelets, neutrophils

18
Q

when are platelets indicated

A
19
Q

what is the aspirate for

A

provides a film

20
Q

what is the trephine for

A

core of bone allows assessment bone marrow cellularity, architecture, presence infiltrative disease

Haematology (12 decks)

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