Pancuronium (Pavulon)

Question 1

Pancuronium (Pavulon) class

Answer 1

Steroidal long acting non-depolarizing neuromuscular blocking agent

Question 2

Pancuronium (Pavulon) MOA

Answer 2

Binding of of NMBD as competitive antagonist to the alpha subunit of the nicotinic receptor inactivating the Na channel & preventing depolarization of the endplate region

Question 3

Pancuronium (Pavulon) dosage

Answer 3

Int: 0.08-1.8 mg/kg
Flood 0.8mg/kg

Maintenance: 0.01-0.02 mg/kg

Question 4

Pancuronium (Pavulon) characteristics

Answer 4

O: 1-4 min

P: n/a

D: 40-90 min

Question 5

Pancuronium (Pavulon) E/M

Answer 5

H/l: 132 min
40-60% cleared by kidney, 11% bile, 15-20% met by deacetylation in liver

Accumulation of 3OH metabolites responsible for prolongation of block

DOA increased in elderly and R.F

Question 6

Pancuronium (Pavulon) considerations

Answer 6

A/E: tachy, HTN, apnea, bronchospasm, salivation, flushing;

Stable for 6 mos at room temp;

Direct vagolytic effect, blocks muscarinic receptors on sympathetic postganglionic nerve terminals resulting in tachy.