Diazepam Flashcards
1
Q
Diazepam class
A
Benzodiazepine
2
Q
Diazepam MOA
A
Binds to GABA(A) receptors, increases Cl permeability leading to hyperpolarization & inhibition of neuronal firing
3
Q
Diazepam dosage
A
Ind: 0.5 - 1 mg/kg
Seizure: 0.1 mg/kg q 10-15 min (max 30 mg)
4
Q
Diazepam characteristics
A
O: 1-5 min
P: 5-15 min
D: 15 min to an hour
5
Q
Diazepam E/M
A
Hepatic microsomal enzymes using oxidative pathway of N-demethylation
6
Q
Diazepam considerations
A
Reduces requirements for VA;
Elderly have decreased clearance & dosage requirements;
May cause neonatal hypothermia
