Methergine

Question 1

Methergine class

Answer 1

Semi-synthetic ergot alkaloid

Question 2

Methergine MOA

Answer 2

Acts directly on smooth muscle of uterus and increases tone, rate, & amplitude of rhythmic contractions. Induces a rapid and sustained tetanic uterotonic effect which shortens the 3rd stage of labor & reduces blood loss

Question 3

Methergine dosage & supply

Answer 3

Dose: 0.2 mg
Supply: 0.2mg/ml

Question 4

Methergine characteristics

Answer 4

O: IV immediate, 2-5 min IM, 5-10 min PO

P: 2-3 min or less

D: 20-30 min

Question 5

Methergine E/M

Answer 5

Hepatic metabolism & secretion

Question 6

Methergine considerations

Answer 6

Overdose sx: N/V, oliguria, abd pain, numbness, tingling of extremities, rise in BP followed by hypotension, resp dep, hypothermia, convulsions, coma.

C/I: HTN, toxemia, pregnancy