Panctreaticobiliary and Liver Flashcards
What cyst is this and how to treat?
Type I.
Resection with Whipple.
Mutation in JAG1 and NOTCH?
Alagille syndrome
Lack of bile ducts. Cholestatic jaundice.
Triangular face
Butterfly vertebrae
Heart murmur
20-30% liver transplant
Mutation f Alagille syndrome?
AD
JAG1 and NOTCH
Liver histo with concentric periportal fibrosis
PSC
Liver histo with rosettes, lymphocytes, plasma cells, interface hepatitis
AIH
Liver histo with PAS positive, diastase resistent granules
A1AT
Defect of ATP7B
Wilsons Disease
Wilsons gene defect?
ATP7B
Defect ATP8B1
progressive familial intrahepatic cholestasis
Liver bx with mixed portal tract inflammation with portal venule endothelialitis
Acute cellular rejection
Acute cellular rejection liver bx results
mixed portal tract inflammation with portal venule endothelialitis
hereditary pancreatitis in an autosomal dominant pattern due to premature activation of trypsin
PRSS1
nherited in an autosomal recessive pattern and causes pancreatitis through lowering the levels of trypsin inhibitor
SPINK1
failure of alkalization of the acinar cells with resulting retention of zymogens in the pancreatic duct and digestion of pancreatic tissue
CFTR
Which choledococele requires endoscopic sphincterotomy?
What other abnormality is assoiciated with and what should you recommend in these patients?
Type III
APBJ
Needs cholecystectomy
Which choledococyst has high malignancy potential?
I and IV
FAP patient with hx colectomy presenting witha cute pancreatitis?
Think NSAID sulindac
Seizures and bipolar with acute pancreatitis?
Think valproic acid
Bilateral gynecomastea and acute pancreatitis?
Think marijuana
What skin lesion is found in glucagonoma?
Necrolytic migratory erythema
Pt with obstruction, what is this a sign of?
Annular pancreas
What liver injury does valproic acid cause on histology?
What other things cause this pattern?
Microvescicular steatosis of liver
Acute fatty liver of pregnancy
Tetracycline
MTX
Amiodarone
Tamoxifen
Reyes syndrome
Mitichondrial disorders
Chronic diarrhea with IDA and recurrent pancreatitis?
Why cause this?
Celiac disease
Papillary outflow obstruction
What size important to remember sporatic ampullary adenoma treatment?
<2-3cm and no lymph node involement can resect endoscopically
When not to use LR for pancreatitis?
Hypercalciumeia pancreatitis
Indication to perform ERCP in gallstone pancreatitis?
Cholangitis
When is SOD manometry abnormal pressure?
>40 mmHg
If patient has divism and recurrent pancreatitis what should you do?
ERCP and minor papillotomy
Which pancreatic cystic neoplasm presents in woman aged 20-30? Worried for malignancy?
Solid pseudopapillary neoplasm
Moderate to high malignancy potential range
Bloody fluid with cytology showing finger-like projections (pseudopapillae)
Pancreatic cyst with aspiration showing elevated CEA and amylase?
3 risk factors for resection?
IPMN
>3, dilated PD, nodule/solid components
What type of cells of pancreatic cyst are cuboidal?
Serous cystadenoma
What type of cells from pancretic cyst and culumnar?
IPMN
Cyst in female with low CEA and low amalyse?
Management?
Serous cystadenoma
No surveilance needed!
Difference in IPMN vs mucinous cystadenoma?
IPMN males+femals, MCA females only
IPMN more likely head
MCA more likely body/tail
Difference between AIP type I and type II?
Cell type differences?
Which one is associated with IgG4 elevation?
Which one associated with IBD?
Type I IgG4
Type I Lymphocytoplastic
Type II granulocytic and epithelial
IBD with type II
Why do celiac patients have chronic pancreatitis?
Effacement of duodenal cells leads to loss of CCK and secretic which stimulate enzyme secretion and production
Unresectable pancreatic mass with biliary obstuction?
EUS hepaticogastrostomy vs SEMS if >3 months to live
If <3 months, plastic is okay
Malignent gastroduodenal obstruction?
>6 months?
< 6 months?
>6 months, GJ
< 6 months, enteral stent
Biliary decompression first if hepatic obstruction present
What kind of gallstone?
Sickle cell, HHS
Black pigment (bilirubin)
What kind of gallstone?
Cirrhosis
Black pigment (bilirubin)
What kind of gallstone?
Recurrent pyogenic cholangitis
Brown pigment stones
What kind of gallstone?
TPN
Cholesterol
What kind of gallstone?
Pregnent, OCP, female?
Cholesterol
What kind of gallstone?
Neufibromatosis -
diarrhea, diabetes, biliary dyskenesia
Somatostatinoma with cholesterol stone
What helps cholestatsis in cystic fibrosis?
UDCA
What kind of gallstone?
Ceftriaxone
Crystal calcium ceftriaxone stones
Secretory diarrhea, dermatitis (necrolytic migratory erythema), diabetes
glucagonoma
Dx: glucagon >500
Tx: local surgical resection
mets octreotide
Mass in tail of pancreas with watery diarrhea with hypokalemia and hypochloremia?
VIPoma
>75
MCC mets to pancreas (2)?
RCC and melenoma
Stool gap and meaning
290 - 2(Na+K)
<50 secretory
>50 osmotic
(carb mal, laxatives)
How to differentiate hypoglyemia from insulinoma vs insulin administration?
What syndrome is it related to?
C-peptide is HIGH with insulinoma
MEN1 (AD; chrome 11 melin)
Hyperprolactonemia (gynecomastia), Hyperparathyroidism (elevated calcium),
What is related to von Hippel Lindau?
AD
PNETs
Pheos
Hemangioblastomas
RCC
What is related to Nuerofibromatosis 1?
Somatostatinoma (mild diabetes mellitus, steatorrhoea and gallstones, and achlorhydria, basic stomach contents)
Pheos
Cafe au lait
Neurofibromas
What is related to tuberous sclerosis?
Insulinoma
Angiolipoma
Renal cysts
Rhabdomyoma
Classic XR finding with annular pancreas?
“Double bubble” with dilation of duodenum and stomach
WHen would Peustow procedure be benificial for chronic pancreatitis patient?
If PD duct is dilated >6mm
Liver graft failure in patients with HCV not controlled?
Fibrosing cholestatic hepatitis
RUQ pneumatosis think…
Enphesematous cholecystitis
Tx: Abx and perc chole (same as acalculous cholecystitis)
Asian woman with round nodules in gallbadder and cholecysttis
Xanthogranulomatous cholecytits
All patients with porcelain gallbladder get what
Cholecystectomy
What is next step in transect bile duct?
Percutaneous transhepatic cholangiogram then surgical or endoscopic HJ
Difference between PSC and HIV cholangiopathy on MRCP?
AIDS cholangiopathy has ampullary stenosis
Air with pain in retroperitoneal space?
Duodenal perforation (can be from ERCP)
Tx: often can be treated conservatively
What injury is common when “shortening the scope” on ERCP?
Lateral wall perforation which needs to be treated surgically
Patient crashing with hypotension and hypoxia during ERCP?
Air embolism
Put in Trendelenburg and call emergency team
Oily skin lesions + weight loss + pantreatitis
Acinar cell carcinoma of pancreas
ALT:LDH level is what important number?
<1.5 is more likely shock or DILI
Giant hemangioma is associated with what?
DIC
Kasabach-Merritt syndrome
What is Kasaback Merritt syndrome?
DIC and giant hemangioma
Young women with fever, elevated LFTs and RUQ pain with normal US? Think of…
Fitz-Hugh-Curtis and Chlamydia PID infection
- get pelvic US and IV ceftriaxone
Injury zone in Budd-Chiari?
Zone 3 portal lobules
Compensatory caudate lobe hypertrophy because of accessory hepatic vein drainage directly into IVC
Acute ascites and abdominal pain in pregnent woman?
Think Budd-Chiari
Diagnosis for Pa02 and A-a gradient in HPS?
and what level precludes transplant?
What about contrast TTE results?
What about TcMaa level?
an what level precludes transplant?
Pa02 <70 or Aa gradient >20
No transplant <50
Contrast in cardiac cycle >3 = intrapulm shunt
<3 = intracardiac shunt
TcMAA >5% = intrapulm shunt
>40% precludes transplant
What is routine screen on pregnent patient with cirrhosis?
What size for surgery?
What else should you screen for?
Doppler US to look for splenic artery aneurysm
>2cm
Varices
What type of delivery is best for cirrhotic patient with varices?
Vaginal
2 risks for HCV vertical transmission?
Fetal scalp monitoring
Prolonged laboring (membrane rupture)
Can you breastfeed in HepC? What about HepB?
Yes to both
Best HepB for pregnancy treatment?
tenofovir
Give if >200,000 at 28 weeks
What HBV genotype responds best to PEG and which one worst?
A best (african american)
D is worst (eastern european and asian)
Which HBV genotype has worst prognosis?
C
B is better, C is crummy in Asians