High Yield Book Flashcards

1
Q

Two conditions with temperature-pulse dissociation?

A

Leiptospirosis - doxycycline
Typhoid fever - fluoroqinolone

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2
Q

Diarrhea + dysmotility + heart failure + nueropathy

A

Amyloidosis

Secondary = AA

Primary = AL light chains

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3
Q

What size of fibrovascular polyp of esophagus can you snare if no vessels?

A

<2 cm

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4
Q

Rare reaction to mesalamine?

A

Pericarditis

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5
Q

Nodules throughout GI tract with path showing “needle shaped clefts”

A

Cholesterol emboli to GI tract

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6
Q

What vessel abnormality can cause solid food dysphagia?

A

R subclavian artery

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7
Q

Fever + diarrhea + VitB12 + AIDS

A

Cryptosporidium

Tx: anti-retrovirals and nitazoxanide

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8
Q

Recurrent abdominal pain + lip swelling

What is deficiency?

What can you give to prevent attacks?

A

Hereditary angioedema

C1 esterase activity

Tx: infuse c1 esterase

ppx with Danozol

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9
Q

Sudden outbreak of seborrheic keratosis in elderly patient?

A

GI malignancy

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10
Q

Development of acanthosis nigricans without diabetes?

A

GI malignancy

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11
Q

New diabetes + dermititis + diarrhea

A

Glucagonoma

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12
Q

plucked chicken skin + GI bleeding

A

pseudoxanthoma elasticum

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13
Q

Dysphagia with keratoderma of palms and soles of feet?

What’s the do not miss?

A

Tylosis

SCC of the esophagus

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14
Q

Multiple GI harmartomas with hair loss and nail involvement?

A

Cronkhite-Canada syndrome

(not inherited)

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15
Q

Thickend gastric folds with bx showing corkscrew foveolar hyperplasia

A

Menetrier’s

Tx: H pylori

Antiepidermal growth factor receptor antibody

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16
Q

Two conditions associated with A1AT not to miss?

A

Cervical artery dissection

Neutraphilic panniculitis

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17
Q

Gallbladder polyp any size with stones?

A

cholecystectomy

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18
Q

Any concern for acute mesenteric ischemia or superior mesenteric artery embolism? Next step?

A

IR and amergent angiography

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19
Q

Timing difference for post BMT and GVHD vs VOD?

A

VOD is 21 days

GVHD is 100 days

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20
Q

GI tract tumor that appears green and stains +myeloperpxidase? What is major risk?

A

Granulocytic sarcoma (extrameddulary myeloblastoma) called a CHLOROMA

Risk of AML leukemia

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21
Q

Young women with cramping and abdominalpain worse during period and improves with NSAIDs?

A

Endometriosis

Can see noduels that come and go in GI tract

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22
Q

Tx for severe scute cryoglobulinemia?

A

Plasmapharesis

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23
Q

Harmartomas throughout GI tract?

What is mutation?

3 cancer risks?

A

Cowdens

PTEN (Cowden wears number 10 with cow utters and large thyroid and cervix)

Thyroid, breast, endometrial

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24
Q

Side effec of furosemide?

A

Pancreatitis

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25
Q

AIDS and infection with Bartonella with enlarged liver?

A

Peliosis

Liver cysts that communicate directly with sinusoidal system

Tx Bartonella with erythromycin

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26
Q

Name most likely pathogen and how to treat:

diarrhea after raw shellfish

A

Vibrio

Supportive care

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27
Q

Name most likely pathogen and how to treat:

chocolate milk

A

Listeria

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28
Q

Name most likely pathogen and how to treat:

Fried rice

A
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29
Q

Name most likely pathogen and how to treat:

bloody diarrhea and undercooked beef

A

E coli EHEC 0157:H7

HUS/TTP

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30
Q

Name most likely pathogen and how to treat:

Diarrhea on cruise ship

A

Norovirus

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31
Q

Name most likely pathogen and how to treat:

Diarrhea pet turtle

A

Salmonella

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32
Q

Name most likely pathogen and how to treat:

diarrhea cirrhosis, sepsis and death

A
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33
Q

Name most likely pathogen and how to treat:

MCC travelers diarrhea

A

E coli

ETEC (enterotoxigenic)

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34
Q

Two small bowel infections with PAS+?

A

Whipple

MAC (+AFB)

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35
Q

MCC secondary lymphangiectasia?

A

Heart failure

Sarcoid

Retroperitoneal fibrosis

Sarcoidosis

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36
Q

Mechanism of linaclotide

A

guanylate cyclase receptor agonist

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37
Q

Mechanism of lubiprostone?

A

Chloride channel 2 receptor agonist

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38
Q

Post operative ileus medication?

A

Alvimopan

peripheral mu antagonist

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39
Q

Mechanism of Baclofen?

A

GABA agonist

40
Q

HIV CD4<200 and diarhea with:

tenesmus, bloody diarrhea and paresthesias in saddle area

A

HSV proctitis

41
Q

HIV CD4<50 and diarhea with:

colonic biopsy with acid+ foamy macrophages

A

MAC

look for bulky lymphadenopathy

Tx ethanbutol/rifabutin with azithromycin

42
Q

HIV CD4<200 and diarhea with:

flask shaped colonic ulcers and motile trophozoites

A

Entamoeba histolytica colitis

Tx: Flagyl followed by paramomycin

43
Q

GI infections causing terminal ilieitis?

A

TB

Salmonella

Yersina

MAC

44
Q

HIV CD4<200 and diarhea with:

colonic ulcers with owl eyes inclusion bodies

A

CMV

45
Q

HIV CD4<200 and diarhea with:

eosinophilia and voluminous diarrhea

A

Isospoa bellie enteritis

(Charcot Leyden crystals in stool)

Intracytoplasmic vacules (unlike crypto)

Tx: Bactrim

46
Q

HIV CD4<200 and diarhea with:

fever, diarrhea, terminal ileitis and cholecystitsi

A

Cryptosporidiosis

Tx: immunosuppressive therapy and maybe nitazoaxanide

(no intracelluar vacules like isoospora belli)

47
Q

Left sided abdominal pain with focal area of fat on CT with a line through it?

How treated?

A

Epiploic appendagitis

Tx: NSAIDs (not surgery)

48
Q

Intense abdominal pain after excercise with fever and elevated ESR?

Treatment?

A

FMF (defect encodes protein called pyrin)

Tx: colchicine

49
Q

Gastric mass:

hypoechoic 4th layer with c-kit+ CD117

When to remove? When to treat with what type of chemo?

A

GIST

arrises from interstitial cells of Cajal

(10-30% malignancy)

Remove when >3cm

50
Q

Gastric mass:

hypoechoic 4th layer, actin+, negative c-kit

A

Leiomyoma

51
Q

Gastric mass:

Extramural, anechoic spherical structure at site of subepithelial bulge

A

Duplication cyst

52
Q

Gastric mass:

hyperechoic well circumscribed arrising from 3rd layer

A

Lipoma

53
Q

What layer is lipoma arise from ?

A

3rd layer

54
Q

Gastric mass:

Elevated gastrin, hypoechoic and 2nd/3rd layers

A

Carcinoma

Type I: elevated gastrin with atrophic gastritis

Type II: elevated gastrin with ZES

Type II: normal gastrin (high malignancy - surgically resect)

55
Q

Gastric mass:

hypoechoic 4th layer, actin+, vimentin+, c-kit negative

A

Glomus tumors

Arise from smooth muscle of blood vessel

Negative malignancy potential

56
Q

Gastric mass:

hypoechoic 4th layer, S-100+

A

Swannoma

57
Q

Gastric mass:

hypoechoic mass arising from 3rd layer with central umbilication

A

Pancreatic rest

58
Q

Dysphagia and a shawl like rash and rings around eyes with weakness in proximal muscle groups and nodules on knuckles

Which muscles are involved?

Treatment?

A

Dermatomyositis

Weakness of the striated muscle in the proximal esophagus

Tx: steroids

59
Q

Systemic sclerosis affects what muscles?

A

Fibrosis of smooth muscles

60
Q

CEA level of pancreatic cyst that is worrisome?

A

>192

61
Q

Brain imaging with occipital calcifications?

A

Celiac disease

(also related to seizures)

62
Q

Thickend gallbladder wall appears to invaginate on itself?

Management?

A

Adenomyomatosis

Benign - NTD

63
Q

What stool test to distuinguish pancreatic enzyme deficiency from fat malabsorption?

A

Sudan stain checking for triglycerides

64
Q

Young patient from Middle East with paraproteinemia (elevated alpha chain) and small bowel bx with dense lymphoplasmacytic infiltrate?

A

Immunoproliferative small intesinal disease (IPSID)

Associated with Campylobacter jejuni

Tx: Ampicillin and Flagyl, chemo and radiation

65
Q

Two cutaneous and visceral carvernous hamangioma syndromes?

Which one has bone-overgrowth, soft tissue hyperplasia and varicose veins?

A

Blue rubber bleb nevus syndrome

Klippel-Trenaunay-Weber has the bone-overgrowth

66
Q

TI resection of greator or less than 100cm is what mechanism and how treated?

A

<100cm = cholestyramine

>100- fat malabsorption, medium chain FAs

67
Q

Stool gap for chronic diarrhea and what does pH tell you?

A

Gap >50 is osmotic

pH <5 is sugar malabsorption

pH >5 is probably laxative

68
Q

Chronic pancreatitis resulting in gastric outlet obstruction?

A

Groove pancreatitis causing fibrosis and duodenal obstruction

69
Q

Heriditary colorectal cancer syndrome buzzword:

Mandibular osteoma

A

FAP

APC on chrome 5

Mandibular and skull osteomas, desmoid tumors, lipomas, epidermoid cysts, sebaceous cysts

Brain medulloblastomas and gliomas

70
Q

Heriditary colorectal cancer syndrome buzzword:

Ureteral cancer

A

HNPCC -Lynch syndrome

Mismatch repair MLH1, MSH2

Ureteal cancer, ovarian, stomach, small intestine, biliary tree

3 close relatives, 2 generations, 1 before age 50

71
Q

Heriditary colorectal cancer syndrome buzzword:

Facial angiofibromas (adenoma sebaceum)

A

Tuberous sclerosis

Diffuse hamartoma with colonic ganglioneuromas and schwann cells

72
Q

Heriditary colorectal cancer syndrome buzzword:

Medulloblastoma

A

FAP

73
Q

Heriditary colorectal cancer syndrome buzzword:

Trichilemmoma

A

Cowdens Syndrome

74
Q

Heriditary colorectal cancer syndrome buzzword:

Sertoli cell testicular tumors

A

Peutz-Jeghers syndrome

Chrome 9 serine threonine kinase

Diffuse harmartomous polyps

Extracancers include sertoli testicular tumors, ovarian sex cord tumors, pancreatic tumors

75
Q

UDCA in PBC does not improve what two things?

A

Osteoporosis and fatigue

76
Q

Which BB is preferred in pregnancy?

A

Propranolol

77
Q

What syndrome increases risk of esopahgeal SCC with keritonosis of hands and feet?

A

Tylosis

keritonosis of hands and feet

and FAMMM

78
Q

Syndromes associated with increased risk of pancreatic cancer that warrents surveilance?

A

Puetz Jegger (STK11/LKB1)

Heriditary Pancreatitis

FAMMM (CDKN2A)

Lynch (HPSS)

79
Q

Patient with peripheral fat necrosis and lipase hypersecretion syndrome?

A

Acinar cell pancreatis cancer

80
Q

MCC neonatal hepatitis?

A

A1AT

abn folded protein accumulating in ER”

81
Q

Treatment of primary lymphangiectasia?

A

Low fat diet with medium chain triglycerides

82
Q

Complications of intestinal transplant?

A

PTLD

CMV

Rejection

83
Q

Diarrhea, dermatitis and dementia?

A

Pellagra

B3 Niacin dificiency

Check urinary N methyl -nicotinamide

84
Q

Diarrhea with anemia and neutrapenia

A

Copper

85
Q

Why is enteral feeding good for pancreatitis?

A

Decreases risk of bacterial translocation

86
Q

Hypercholesterol dementia dermatitis

A

Magnesium

87
Q

Follicular hyperkeratosis and night blindness

A

Vit A deficiency

88
Q

Glucose intolerance + peripheral neuropahty + encephalopathy

A

Chromium

89
Q

Hep E infection form wild boar/game:

Tx?

A

Immunocompetent: observe

Solid organ transplant: Riboviron 3 months

90
Q

Sofosbuvir

What genotype?

Can’t give to?

Special considerations?

A

All

GFR <30

91
Q

Sofosbuvir + Ledipavir

What genotype?

Can’t give to?

Special considerations?

A

No 2,3 (harvoNI !)

GFR <30

92
Q

Sofosbuvir + Velpatasir

What genotype?

Can’t give to?

Special considerations?

A

All

GFR <30

93
Q

Sofosbuvir + Voxilaprevir

What genotype?

Can’t give to?

Special considerations?

A

All

GFR <30

Great for previously treated and failed SVR

94
Q

Elbasvir + Grazoprevir

What genotype?

Can’t give to?

Special considerations?

A

No 3 (Check your elbow when shotting 3s)

Decompensated cirrhotics

PPI OKAY

95
Q

Glecoprovir + pibrentasivir

What genotype?

Can’t give to?

Special considerations?

A

All genotypes

Can give to ESRD and cirrhotics

Avoid statins

96
Q

European child with bone fractures and hepatomegaly

A

Gouchers (lipid layden bx)

Glucocerebrosidase deficiency

HCC and blood malignancy risk

Tx: eliglustat

97
Q
A