Pancreatitis 2 Flashcards
What is the cause of congenital cysts?
most likely due to anomalous pancreatic duct development
Describe the make up of congenital cysts.
Unilocular, thin-walled cysts with a thin, fibrous capsule filled by clear serous fluid
Congenital cysts may be sporadic but they can also be part of what inherited conditions?
Autosomal-dominant polycystic kidney disease
von Hippel-Lindau disease
What are autosomal-dominant polycystic kidney diseases?
cysts in liver, kidney and pancreas
What is von Hippel-Lindau disease?
vascular neoplasms are found in the retina and cerebellum or brain stem in association with congenital cysts (and also neoplasms) in the pancreas, liver, and kidney
When are pseudocysts formed and what are they caused by?
Formed when areas of intrapancreatic or peripancreatic hemorrhagic fat necrosis caused by acute pancreatitis or traumatic injury are walled off by fibrosis and granulation tissue
Do pseudocyst have an epithelial lining?
no
What are pseudocysts lined by instead of epithelial lining?
fibrin and granulation tissue
Where are serous cyst adenomas mostly found?
tail of pancreas
How would you treat serous cystadenomas?
surgical resection
Describe the make up of serous cystadenomas.
Glycogen-rich cuboidal cells surrounding small cysts containing clear, straw-colored fluid
What are mucinous cystic neoplasms?
precursors to invasive carcinomas, painless, slow-growing masses arising in the tail
What are the cysts in muscinous cystic neoplasms lined by (type of epithelium)? and what are they filled with?
cysts are filled with thick, tenacious mucin, and lined by a columnar mucinous epithelium with an associated densely
cellular stroma (resembles ovarian stroma), that expresses ER/PR receptors and Inhibin
What type of mutation are linked to mucinous cystic neoplasms?
- Kras mutations in in 50% cases, 1/3rd cases will harbor an invasive adenocarcinoma with TP53 and SMAD4 mutations
What are intra-ductal papillary mucinous neoplasms?
Cysts that ontain mucin, lack dense “ovarian” stroma (unlike mucinous cystic)