Diseases of the GB 1 Flashcards
Bile in the gallbladder is bile salts or bile acid form?
bile salts in gallbladder
Explain the synthesis of bile salts.
How does FGF19 suppress synthesis of bile acids?
suppresses synthesis of bile acids from cholesterols by inhibiting cytP450
Cholesterol stones are formed due to excess of cholesterol in relation to what other molecules?
phospholipids and bile acids
In what conditions are pigment stones common?
in hemolytic anemias; such as sickle-cell disease and hereditary spherocytosis
What type of patients that present with cholelithiasis but are asymptomatic may also be recommended for a cholecystectomy?
immunocompromised patients
diabetics
morbidly obese
etc.
What is a biloma?
Collection of bile within the abdominal cavity
When is it likely to have abiloma?
when there is a lie leak for example after laparoscopic cholecystectomy
What is gallstone ileus?
rare but when in cases of severe inflammation the gallstone erodes through the gallbladder into adherent bowel potentially causing obstruction
Cholecystoenteric fistula
can be caused if you don’t remove a gallstone at an early age/ The stone erodes through the gallbladder into the adherent bowel
Can potentially cause obstruction
What are things that can cause calculus cholecystitis?
- salmonellosis
- polyarteritis nodosa
- GB sludge
- blockage from a tumor
- Prolonged fasting
What are some clinical manifestations of acute choelcystitis?
Be able to understand this chart.
Understand flow diagram.
Where is Boas’s sign felt?
pain in the area below the right scapula
Does cholecystitis manifest with jaundice?
no; jaundice only occurs when CBD is obstructed.
