Pancreatic neoplasms

Question 1

familial syndromes associated with pancreatic cancer

Answer 1

HNPCC
BRCA 2
FAP
Peutz-J

Question 2

Gastrinoma triangle

Answer 2

2nd and 3rd part duodenum
cystic duct
neck and body of pancreas

Question 3

genetic mutations associated with PC

Answer 3

kRAS 2

TS genes: p53, p16, DPC4

Question 4

clinical presentation of PC

Answer 4

painless obs jaundice
weight loss
upper abdo pain that radiates to back
late onset DM
GOO
Ascites
Abdo mass
Thrombophlebitis migrans-paraneoplastic phenomenon
Dyspepsia

Question 5

best imaging for pancreatic cancer

Answer 5

U/S to start (ascites, biliary obs, panc and biliary duct)
CT- contrasted is best-vessels and primary tumour

Question 6

what is a whipples procedure

Answer 6

it is a pancreaticoduodenectomy

resect head of pancreas, duodenum and bile duct and basically connect to jejenum (hepaticojej, pancreaticojej, gastrojej)

Question 7

best way to diagnose an insulinoma

Answer 7

EUS

Question 8

risk factors for bile duct malignancy

Answer 8

PSC
ULC COLITIS