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GI > Pancreatic enzymes > Flashcards

Pancreatic enzymes Flashcards

1
Q

What secretes digestive enzymes

A

Acinar cells

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2
Q

Pancreatic islet includes…

A

Alpha, beta and acinus

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3
Q

Alpha cells secrete

A

glucagon

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4
Q

Beta cells secrete

A

insulin

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5
Q

Which cells produce bicarbonate?

A

Centrocinar cells

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6
Q

2 main pancreatic proteases in zymogen form

A

Trypsinogen and chymotrypsinogen

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7
Q

Cephalic stage

A

Vagal innervation and gastrin production in response to seeing food/smelling food

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8
Q

Second stage

A

Low level stimulus in anticipation of a meal

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9
Q

Stimulus for secretin

A

Low duodenal pH

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10
Q

Where is secretin produced?

A

Upper small intestine

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11
Q

What does secretin do?

A

Pancreatic water and bicarb secretion (carrying enzymes)

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12
Q

What stimulates cholecystokinin?

A

HCl, protein and fats entering duodenum

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13
Q

Where is cholecystokinin produced?

A

I cells of duodenum and jejunum

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14
Q

What does cholecystokinin do?

A

Pancreatic enzyme and bicarbonate secretion

Gallbladder contraction

Inhibition of gastric acid secretion

Delays gastric emptying

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15
Q

What stimulates gastrin?

A

Gastric distension and irritation

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16
Q

Where is gastrin produced?

A

G cells in stomach

17
Q

What does gastrin do?

A

HCl secretion (parietal cells) and enzyme release (acinar cells)

18
Q

Where is bicarbonate secreted from

A

Epithelial cells in pancreatic duct

19
Q

What does bicarbonate do?

A

Protects duodenal mucosa by neutralising stomach acid, buffers to optimise pH for enzyme digestion

20
Q

What stimulates enzyme secretion?

A

Gastrin and CCK

21
Q

As proteins and fats digested, pH rises meaning

A

Stimuli for CCK and secretin disappear and pancreatic secretion reduces

22
Q

What are consequences of pancreatic exocrine insufficiency?

A

Malnutrition,
Osteoporosis,
Increased cardiovascular morbidity,
Symptom burden

GI (13 decks)

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