Pancreatic Cancer Flashcards
lifetime risk of developing pancreatic cancer is?
1 in 71 or 1.4%
survivorship for person just diagnosd?
5year ish
- Types of cell origins for (exocrine) pancreatic cancers?
- Majority are which type?
- adenoCA = MAJORITY ductal-
- acinar cell carcinoma (very uncommon)
periampulary malignancies-
-why important?
lots of stuff here - bile duct + pancreatic duct + ampulla –> many things in this area = most common area for problems - cant specifically say where tumor originated from so we call it periampullary
Risk factors for pancreatic cancer?
- tobacco
- obesity (inactivity)
- chronic pancreatitis
- Hereditary breast/ovarian cancer (BRCA1/2)
- FAMMM (CDK2N/p16)
- Hereditary pancreatitis (PRSS1, SPINK1)
- Faminial adenomatous polyposis (APC)
most common differential diagnoses when pancreatic mass is found?
- pancreatic cancer (ALMOST ALWAYS)
- mass-forming pancreatitis
Presentation of pancreatic cancer:
1) asymptomatic - CTs and MRIs
2) symptomatic
- pain
- non-intentional WL with anorexia
- jaundice
Important stuff to know with staging-
Clinical approach
clinical staging
Clinical approach = resectable or not?
Clinical staging = Is it in LN or not? and has it metastasized or not?
Treatment for curative intent?
operation + chemo with or without radiation
treatment for palliation?
- chemo for unresectable PanCA
- treat jaundice with stents
- pain with celiac plexus block, pain management
- gastric outlet obstruction: stents and operations
- gastrointestinal dysfunction
- malaise and malnutrition
neoplastic pancreatic cysts:
- MCN - mucinous cystic neoplasms
- IPMN - intraductal papillary mucinous neoplasms
Non-neoplastic pancreatic cysts:
- pseudocysts
- lymphoepithelial cysts
- retention cysts
Common treatment sequence for pancreatic cancer?
chemo (neoaduvant)-surgery-chemo (adjuvant)
Common palliative treatment?
chemo +/- chemo
Main therapy for pancreatic cancer?
surgery! - chemo helps but doesnt cure
