Pancreas Histology

Question 1

acinar cells

Answer 1

secrete digestive enzymes (amylase, lipase, trypsinogen)

release them into the acinar lumen

Question 2

acinar cells

Answer 2

secrete digestive enzymes (amylase, lipase, trypsinogen)

release them into the acinar lumen

Question 3

Ductal cells

Answer 3

secrete water and electrolytes
centroacinar and intercalated duct cells 
secrete bicarb (-buffers pH to prevent enzymes from being activated too early) and maybe mucus

Question 4

a cells

Answer 4

24-25% o islet cells produce glucagon

Question 5

Beta cells

Answer 5

55% of islet cells

produce insulin and amylin

Question 6

PP cells

Answer 6

<2% of cells

produce pancreatic polypeptide

Question 7

PP cells

Answer 7

<2% of cells

produce pancreatic polypeptide

Question 8

insulin

Answer 8

released in response to glucose

promotes glu uptake in target tissues (liver, muscle fat)

Question 9

glucagon

Answer 9

responds to low glucose

promotes production of glucose from liver glycogen and glucose precursors

Question 10

pancreatic polypeptide

Answer 10

stimulates gastric chief cells
inhibits bile secretion and intestinal motility
inhibits pancreatic enzymes and bicarb secretion

Question 11

CIP

Answer 11

similar to glucagon

stimulates pancreatic exocrine secretion, gut activity and motility

Question 12

motilin

Answer 12

increases gastric motility

Question 13

islet acinar axis

Answer 13

pancreas rapidly receives glucose that was absorbed in the stomach, which stimulates digestive enzyme production in the pancreas

-proposed link b/w endocrine and exocrine pancreas such that B cells could affect ductal cells

Question 14

islet acinar axis

Answer 14

pancreas rapidly receives glucose that was absorbed in the stomach, which stimulates digestive enzyme production in the pancreas

-proposed link b/w endocrine and exocrine pancreas