Pancreas CIS Flashcards
(49 cards)
Insulin increases glycogen storage in the ____ and ____.
Liver and Skeletal mm
Insulin promotes glucose uptake and use by _____ and _____.
skeletal mm and adipose tissue
Insulin ________ output by the liver.
Suppresses glucose
Insulin promotes _____ synthesis and storage in the ____ and ____.
- triglyceride
- liver and adipose tissue
Insulin promotes the clearance of ______ from the _____.
- chylomicrons
- blood
Insulin suppresses lipolysis of ______.
adipose triglyceride stores
GLUT2 is insulin ____.
independent
GLP1 potentiates ____ and is used in ______ to encourage insulin release.
- Insulin release
- Type II Diabetes
4 steps of insulin secretion from beta cells
- Glucose enters the cell via GLUT2
- intracellular K increases
- intracellular Ca increases via voltage sensitive Ca2+ channels
- Insulin in released via secretory granules
After meal ingestion, insulin secretion promotes the movement of ____ into the ____.
- Potassium
- intracellular space
4 actions of GLP-1
- inhibits gastric emptying
- promotes insulin release
- inhibits glucagon release
- Suppresses appetite
What is the role of DPP-IV?
to degrade GLP-1
Two drug types used in DMII to promote/ potentiate insulin release?
- GLP1 agonist
2. DPP-IV inhibitors
What does each peak stand for in a double peak appearing in a CGM reading? What may the patient need?
- double peak indicates a high fat meal
peak 1 = carbs
peak 2 = lipids - a second dose of insulin to accommodate for the second peak of fat
CGM reading: in a pt with impaired glucose tolerance, a peak will ______. In a healthy individual we see an______.
- slowly decrease
- abrupt decrease
Long term complications of DM involve which organ systems? (4)
- nervous
- CV
- renal
- sensory organ
_____ is a group of chronic metabolic disorders characterized by abnormality in ______ or actions ________.
- insulin secretion
- resulting in hyperglycemia
_____ results frm absolute deficiency of insulin secretion due to ______.
- Type I DM
- beta cell destruction
Type I DM patients require _____ and are prone to _____.
- insulin
- ketoacidosis
____ results from a combination of _____ and _____, which is often preceded by a period of abnormal ______.
- Type II DM
- Insulin resistance
- insulin deficiency
- carbohydrate metabolism
DM type II patients are typically ____, may not ______, and are usually not prone to _____.
- over weight
- immediately require insulin
- ketoacidosis
_____ represents diabetes diagnosed during pregnancy.
Gestational DM
Type I DM age of onset
peak in early childhood and adolescence
Pathophysiology of Type I DM
Autoimmune disease
