Adrenal Gland

Question 1

ACTH stimulates the release of ____

Answer 1

DOPA

Question 2

Synthesis of Epi?

Answer 2

Dopamine -> NE -> E

Question 3

Dopamine is synthesized in the cell ____

Answer 3

cytosol

Question 4

NE is synthesized within a ____

Answer 4

Chromaffin granule

Question 5

Epi is synthesized in the cell’s _____

Answer 5

cytosol

Question 6

NE and E are stored in the cell’s ____

Answer 6

cytosol

Question 7

What 3 things can me measured to determine catecholamine production? Which is found in urine?

Answer 7

1. catecholamines (NE and E)
2. metanephrines
3. vanillylmandelic acid (VMA) (in urine)

Question 8

What enzyme is responsible for the break down of NE and E?

Answer 8

COMT = catecholamine-O-methyltransferase

Question 9

E has a higher affinity for what receptor type?

Answer 9

beta 2

Question 10

Beta 2 receptors are found in what type of tissue? (4)

Answer 10

liver, smooth mm of vessels, bronchioles, uterus

Question 11

Beta 1 receptors are found in (1)?

Answer 11

the heart

Question 12

Alpha 1 receptors are found in (1)?

Answer 12

postsynamptic sympathetic nerve terminals

Question 13

alpha 2 receptors are found in (2)?

Answer 13

presnyaptic sympathetic nerve terminals,

beta cells of pancreas

Question 14

Define a Pheochromocytoma?

Answer 14

tumor of the chromaffin tissue

Question 15

Pheochomocytoma produce excessive ______.

Answer 15

chatecholamines

Question 16

triangle of pheochromocytoma symptoms

Answer 16

• headaches
• sweating (diaphoresis)
• palpitations