Palliative medicine Flashcards
3 parts to palliative care
Physical
Psychosocial
Spiritual
3 reasons for Sx relief in palliative
Reduces QoL
Causes distress
Results in admissions
Name 3 causes of nausea and vomiting
Bowels - Mucositis, constipation, infection, obstruction
Brain 0 raised ICP
Biochemical - Medications, hypercalcaemia, uraemia, infection, hypomagnaesaemia
How do these places play a role in Nausea
Gut wall?
Chemoreceptor trigger zone?
limbic?
vestibular?
Gut wall: distension stimulates vagus - constipation, obstruction, chemo stimulates enterochromaffin cells
Chemo - uraemia, drugs, chemotherapy, hypercalcaemia
Limbic - emotion
Vestibular - motion sickess / vertigo
Name some antiemetics ///
Bowel only cause
Domperidone Hyoscine butylbromide
Bowel+brain
Haloperidol / metoclopramide
Brain
cyclizine / levopromazine
Why shouldn’t you prescribe cyclizine and metoclopramide
c - constipating
M - diarrhoea
Counteract each other in bowel
What is pain
An unpleasant sensory and emotional experience associated with actual or potential tissue damage
Goals of Nx in pain
A good night’s sleep
Pain free at rest
Pain free on movement
When is the WHO pain ladder used
Cancer pain
3 Stages of pain ladder and Eg of 2 drugs in each
Simple
-Para / NSAIDs
Weak opiods
Codeine / tramadol
Strong
-Morphine, oxycodone, buprenophine, fentany, methadone, ketamine
When you move from weak opiods to strong do you continue the weak?
All have a CEILING EFFECT therefore REPLACE with strong opioid rather than add
Which do we prefer morphine or oxycodone?
Oxycodone - stronger + less SEs
Can get tablets and immediate release
-Deal with background and breakthrough pain
Common SEs with morphine?
Constipation, sedation, nausea, dry mouth
[-> Stimulant laxatives + PRN antiemetics]
Intresting Resp fact with opiates?
tend to reduce RR BUT increase tidal volume!
Which can you give if RR<8 AND SpO2 <92% due to opioids?
Naloxone