Pain Management - Chronic Flashcards

1
Q

Signs and Sxs of Persistent Pain

A
  • depression, anxiety, sleep disturbances
  • frustration, anger
  • decreased self esteem, social involvement, libido
  • financial stresses, work issues, altered family dynamics, legal issues
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2
Q

Treatment Goals for Chronic Pain

A
  • increase tolerance for physical activity
  • decrease suffering and pain
  • decrease reliance on healthcare system
  • decrease reliance on medications
  • return to work or other functional role in society
  • develop appropriate strategies for self-management
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3
Q

General Strategies for Chronic Pain

A
  • taper use of inappropriate meds
  • provide education about chronic pain
  • focus on increase in function and physical activity
  • establish a time frame for achieving goals
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4
Q

Nonpharm Options for Persistent Pain

A
  • TENS
  • biofeedback
  • PT if appropriate
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5
Q

List 3 pharm options for persistent pain.

A
  • non-opioids: NSAIDs and APAP
  • tramadol
  • opioids
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6
Q

How Are Opioids Used in Treating Chronic Pain

A
  • scheduled regular release product
  • PRN regular release product for breakthrough pain
  • consider changing to sustained release product when adequate scheduled dose is established
  • start a bowel program
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7
Q

List Adjuvant Analgesics for Chronic Pain

A
  • TCAs
  • AEDs
  • SNRIs
  • local anesthetics, eg lidocaine
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8
Q

TCAs MOA

A

-inhibit NE and 5-HT reuptake

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9
Q

TCAs Generic Names

A
  • amitriptyline
  • nortriptyline
  • desipramine
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10
Q

TCAs Onset

A

weeks

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11
Q

AEDs MOA

A
  • decrease synaptic transmission (carbamazepine)
  • inhibit neuronal activity and increase GABA (gabapentin)
  • decrease release of glutamate, NE and substance P (pregabalin)
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12
Q

AEs of Carbamazepine

A
  • CNS

- CYP450 induced

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13
Q

AEs of Gabapentin

A
  • CNS

- GI

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14
Q

Valproic Acid AEs

A
  • GI
  • CNS
  • increased LFTs
  • decreased platelets
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15
Q

Pregabalin AEs

A
  • dizziness
  • sedation
  • dry mouth
  • peripheral edema
  • weight gain
  • blurred vision
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16
Q

SNRI MOA

A

-potent inhibition of NE and 5-HT3 reuptake

17
Q

SNRI Generic and Trade Name

A

duloxetine/Cymbalta

18
Q

What is the indication for duloxetine/Cymbalta?

A

-tx of pain assoc w/ diabetic neuropathy and chronic MS pain due to low back pain and OA

19
Q

How should chronic low back pain be treated?

A
  • APAP first
  • tramadol or opioids in selected patients
  • AEDs or TCAs if neuropathic sxs
20
Q

How should fibromyalgia chronic pain be treated?

A
  • APAP considered 1st (weak evidence)
  • TCAs, AEDs, SNRIs have stronger evidence
  • tramadol better alternative than opioids
  • NSAIDs only with other agents
21
Q

How should neuropathic pain (eg diabetic neuropathy or postherpetic neuralgia) be treated?

A
  • TCAs, SNRIs, AEDs, 5% lido patch considered 1st line
  • tramadol and opioids 2nd line
  • capsaicins 3rd line tx