Pain and thermosensation

Question 1

Pain can be classified into 3 forms, what are they?

Answer 1

Nociceptive
Inflammatory
Pathological

Question 2

What are nociceptors?

Answer 2

Peripheral sensory afferent neurones that are normally activated by intense stimuli that are damaging

Question 3

Which neurones are responsible for pin transmission?

Answer 3

A delta (Thinly myelinated)

C fibres (Unmyelinated)

Question 4

Sub classification of A delta fibres

Answer 4

Type 1(HTM)

Type 2

Question 5

Sub classification of C fibres?

Answer 5

C-MH

C-M

C-H

C-MiHi

Question 6

Where do primary cell bodies terminate?

Answer 6

Centrally in the spinal cord dorsal horn in laminae of Rexed

Question 7

Where are the soma of the sensory neurones in the trigeminal system located?

Answer 7

Trigeminal sensory ganglion

Question 8

What is the primary neurotransmitter in the dorsal horn?

Which receptors does this target?

Answer 8

Glutamate

AMPA and NMDA receptors

Question 9

Which peptides are responsible for assisting in transmission?

Answer 9

Substance P

CGRP

Question 10

Describe peripheral sensitization?

Answer 10

Mediated by nociceptors

Primary hyperagesia

Requires ongoing periph pathology for maintenance

Major role in heat

Question 11

Describe central sensitization?

Answer 11

Secondary hyperalgesia

Pain that persists after tissue healing

Mechanical sensitivity

Question 12

What is visceral pain?

Answer 12

Pain perceived at a distance from the affected organ

Question 13

What is viscerosomatic pain?

Answer 13

Sharp and well localised

Inflamm exudate from diseased organ contacts somatic structure