Pain

Question 1

Is pain discriminative or non-discriminative

Answer 1

non-discriminative

Question 2

What do the experience of pain depend of?

Answer 2

1. Sensory coding of stimuli
2. Motivational/affective component and moments of high stress
3. Cognitive/cultural component.

Question 3

What receptors are responsible for pain and where do they originate

Answer 3

Nociceptors, they originate from the specialised ending of nerve fibres

Question 4

Where is Noxious stimuli transduced? And what are they transduced into?

Answer 4

Transduced into electrical activity at the peripheral free nerve endings of Ad and C nerve fibres.

Question 5

How are nociceptors classed?

Answer 5

1. Temperature
2. Mechanical stimuli
3. Mechanical and thermal stimuli
4. Mechanical, thermal and chemical stimuli

Question 6

When do nociceptors respond?

Answer 6

When stimulus levels are outside the normal range

Question 7

What excites the nocirecptor’s afferent?

Answer 7

Net entry of positive charge (Na+)

Question 8

What ion channel is commonly involved with pain? At what temp is it activated?

Answer 8

TRPV1, activated above 43°

Question 9

What can TRPV1 bind with?

Answer 9

Capsaicin (chilli pepper), allyl isothiocyanate (wasabi) and allicin (garlic)

Question 10

True or false: Is there usually a fast sharp pain (Ad) followed by a slower dull pain (C)

Answer 10

True

Question 11

What is Allodynia?

Answer 11

Innocuous stimuli are felt to be painful

Question 12

What is primary hyperalgesia?

Answer 12

Pain stimuli that causes more intense pain

Question 13

How is Allodynia and Primary Hyperalgesia shown

Answer 13

On damaged skin