Common features neurodegenerative disease

Question 1

What do all neurodegenerative diseases appear to involve?

Answer 1

Involve a change in the shape of a normal protein within neurons. This results in a disease protein called “rogue” protein.

Question 2

The process of acculumation of rogue proteins

Answer 2

1.Shape change in normal protein, resulting in rogue protein.
2. Rogue protein recriut and convert more the normal protein into the abnornal form, in a chain reaction.

Question 3

What does the accumulation of rogue proteins do to organelles and cells?

Answer 3

Rogue proteins accumulate and stick to form insoluble aggregates in vulnerable neurons and glial cells.
This stuffs up the function of many organelles and kills the cell.

Question 4

Where in the cell do problems appear in neurodegenerative diseases?

Answer 4

Mitochondria