Pain Flashcards
Steroidal anti-inflammatory drug prototype
corticosterone
Steroidal anti-inflammatory MOA
Inhibit arachidonic acid synthesis
NSAIDS MOA
inhibit Cox 1 and 2
Cox 1 constituative means
always there
Cox 2 inducible means
get inflammation and get increase in Cox 2
Undesirable effects of NSAIDS
GI irritation, bleeding ulcers, perforations
Cox 2 inhibitor examples
celecoxib, rofecoxib, valdecoxib
Major indications for NSAIDS
inflammatory pain (RA, osteoarthrosis), post-traumatic or post-operative pain, HA, dysmenorrhea
Acetaminophen MOA
distribues to CNS, weak inhibitor COX
Which has less gastic distress NSAIDS or Tylenol?
tylenol
Undesirable effects of acetaminophen
liver damage with OD
Treatment of acetaminophen OD
N-acetylcysteine
Major indications for acetaminophen
HA, fever, osteoarthritis
Do you develop tolerance to constipation with morphine
No
Is opioid withdrawal life-threatening?
No
What are some synthetic opioids?
meperdine, fentanyl, methadone
Meperidine properties
- has toxic metabolite that can build up and cause seizures
- fewer smooth muscle spasms than morphine
- no meiosis
Fentanyl properties
- 80-100 x more potent than morphine
- fast onset, short duration
- available as duragesic patch
- available orally