PAH, PTX, alveolar collapse, atelectasis Flashcards

1
Q

PH - rare incidence but more common in _____

A

obese

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2
Q

PH mean pressure PAP ______

A

> 25 mmHg

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3
Q

requires ______ to definitively diagnose

A

RHC

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4
Q

5 main categories PH falls into

A
  • pulm arterial HTN
  • left heart disease with low EF
  • lung dz/chronic hypoxia
  • chronic thromboembolic
  • unknown etiologies
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5
Q

PAH is an increase in ____

A

vascular tone

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6
Q

increased proliferation of pulm ______ ______ ______

A

vascular smooth muscle

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7
Q

initially reversible smooth muscle vasoconstriction progresses to ______ ______ _______ _____

A

irreversible smooth muscle hypertrophy

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8
Q

right ventricular overload can lead to ____ ______ with decreased _______ perfusion

A

cor pulmonale
coronary

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9
Q

_______ anesthetic if possible

A

regional

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10
Q

if GA then avoid ______ _______ changes

A

major hemodynamic

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11
Q

avoid _____ since it increases PVR

A

ketamine

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12
Q

avoid any situation that would increase SNS output and increase PVR, such as:

A
  • hypoxemia
  • hypercarbia
  • acidosis
  • pain
  • hypothermia
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13
Q

caution in surgery with potential for _____, _____, ______ embolism

A

air, fat, cement

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14
Q

caution in surgery with ___ __________, ______, ________

[Anesthesia management of PH]

A

Elevated airway pressures, laparoscopic, tredelenburg position

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15
Q

___ Hypotension
[PH management]

A

Avoid

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16
Q

If hypotension fails to correct quickly, then suspect that the ____ may be from ___ and not a drop in ____.
[PH management]

A

Low BP, RV Failure, SVR

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17
Q

Lung parenchyma tear or rupture allows air from inside of lung to escape between___and ___ ___, non-communicating with no atmospheric access, no shifting ___ or ___

[Characteristics, simple pneumo]

A

lung, visceral pleura, mediastinum, hemi-diaphragm

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18
Q

Primary Pneumothorax:

A

absence of diagnosed lung disease, healthy

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19
Q

Causes: (3)
[Primary Pneumothorax]

A

subpleural bleb, smoking, Birt-Hogg Dube’ syndrome speculated drop in atmospheric pressure

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20
Q

Secondary Pneumothorax:

A

complication of lung disease

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21
Q

Causes: (9)
[Secondary Pneumothorax]

A

COPD, emphysema, cystic fibrosis, metastasis, necrotizing bacterial lung infections, pneumocystis, TB, pneumonia, fungal, viral

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22
Q

Traumatic pneumothorax: ___(closed/___) or ___ (open/___) ___ trauma (more common)

A

Blunt, non-communicating, penetrating, communicating, thoracic

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23
Q

Iatrogenic:
[Traumatic Pneumo]

A

medical procedure induced

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24
Q

Non-iatrogneic:
[Traumatic Pneumo]

A

External trauma

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25
Q

____/___ (more common):
[Traumatic Pneumo]

A

Communicating/open

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26
Q

___ penetrating injury, air comes from outside, with ___ ___
[Communicating Pneumo part 1]

A

External, atmospheric access

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27
Q

Atmospheric air enters and trapped between ___ ___and___ ___ during inspiration causing a ___ wound and exits chest cavity during ___
[Communicating Pneumo part 2]

A

parietal pleural, chest wall, sucking, expiration

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28
Q

___ moves away from ___ side during ___ and toward the ___ side during ___ (___ ___)
[Communicating Pneumo part 3]

A

Mediastinum, affected, inspiration, affected, expiration, mediastinal flutter

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29
Q

___ air enters ___ chest wound during ___

[Tension Pneumo 1/4]

A

Atmospheric, external, inspiration

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30
Q

___ is not able to ___ chest cavity during ___

[Tension Pneumo 2/4]

A

Air, escape, expiration

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31
Q

Air in chest rapidly accumulates ___ lung on ___ side

[Tension Pneumo 3/4]

A

collapses, affected

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32
Q

Continued ___ ___ builds

[Tension Pneumo 4/4]

A

intrapleural pressure

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33
Q

___, ___, ___ shift to unaffected side

[Tension Pneumothorax Physical Findings]

A

Heart, trachea, esophagus

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34
Q

Large vessels collapse and impede___ ___ into chest cavity resulting in ___ ___ ___

[Tension Pneumothorax Physical Findings]

A

venous return, decreased cardiac output

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35
Q

___ ___ ___ ___ (ventilated patient)

[Tension Pneumothorax Physical Findings]

A

Increased peak inspiratory pressure

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36
Q

Increased ___ and ___ ___veins

[Tension Pneumothorax Physical Findings]

A

CVP, distended neck

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37
Q

Dyspnea, ___, ___, ___

[Tension Pneumothorax Physical Findings]

A

respiratory distress, cough, tachypnea

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38
Q

___or absent ___breath sounds

[Tension Pneumothorax Physical Findings]

A

Decreased, ipsilateral

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39
Q

___(most common sign)

[Tension Pneumothorax Physical Findings]

A

Tachycardia

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40
Q

___ chest pain

[Tension Pneumothorax Physical Findings]

A

Ipsilateral

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41
Q

Hyp__emia

[Tension Pneumothorax Physical Findings]

A

Hypoxemia

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42
Q

Hyp___tension
[Tension Pneumothorax Physical Findings]

A

Hypotension

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43
Q

Hyp___carbia… but ETCO2 ___due to ___ CO!!

[Tension Pneumothorax Physical Findings]

A

Hypercarbia, decreased, low

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44
Q

Tension Pneumothorax Treatment (3)

A

Observation only
Decompression of Pleural Space
Supplemental Oxygen

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45
Q

___ or ___ then observation only

[Tension Pneumothorax Treatment]

A

Asymptomatic, < 15%

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46
Q

Decompression of pleural space
___ angiocath, ___ syringe, 3 ___ ___
Insert at ___intercostal space ___
Or…
Insert at ___intercostal space laterally

[Tension Pneumothorax Treatment]

A

14 g. , 50 cc, way stopcock, 2nd, anteriorly, 4th-5th, laterally

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47
Q

Supplemental oxygen ___ ___ ___

[Tension Pneumothorax Treatment]

A

accelerates air reabsorption

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48
Q

Inhalation of high concentrations of oxygen may speed the ___ of a pneumothorax by reducing the partial pressure of ___ in the pulmonary capillaries,. This should increase the pressure gradient between the pleural cavity, and pleural capillaries, so increasing the absorption of ___ from the pleural cavity
[Tension Pneumothorax Treatment]

A

resolution, nitrogen, air,

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49
Q

Optimizes ___ delivery and ___ ___

[Tension Pneumothorax Treatment]

A

oxygen, gas exchange

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50
Q

Inflammatory condition caused by ___ or ___
Most frequent bacteria: ___

[Pneumonia]

A

bacteria, virus, pneumococci

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51
Q

Alveoli membrane becomes ___ & ___

[Pneumonia]

A

inflamed, porous

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52
Q

Consolidation: Alveoli fills with ___, ___ ___.
Entire lobes can become ___

[Pneumonia]

A

fluid, cell material, consolidated

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53
Q

Reduction in ___-___ surface area

[Pneumonia]

A

gas-exchanging

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54
Q

V/Q ratios decrease: What does this mean? Increased shunt or deadspace? Hypoxemia, Hypercapnia or both?
[Pneumonia]

A

Shunt, Both

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55
Q

Treatment: ___, ___, ___ ___

[Pneumonia]

A

Antibiotics, Resp Rx, VC breaths

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56
Q

A reduction or absence of air in parts of the lung resulting in the collapse of ___, loss of ___ ___, ___-___ shunt and diminished gas exchange.

[Atelectasis]

A

alveoli, lung function, intra-pulmonary

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57
Q

___ reduction or absence of air in parts of the lung
resulting in the ___ of alveoli,
___ ___lung function,
intra-pulmonary ___
___ gas exchange.

A

Atelectasis, collapse, loss of, shunt, diminished

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58
Q

Oxygen concentration:

A

the fraction or percentage of inspired oxygen delivered (FiO2).

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59
Q

General Anesthesia causes ___

A

Atelectasis

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60
Q

General Anesthesia causes Atelectasis
Estimated incidence between ___-___.

A

50-100%

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61
Q

“The prevalence of atelectasis has been estimated to be as high as ___ in patients undergoing ___ ___”

A

100%, general anesthesia.

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62
Q

Average ___, can exceed ___ collapsed lung

[General anesthesia causes atelectasis]

A

3-4%, 20%

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63
Q

Difficult to ___postoperatively
[General Anesthesia causes Atelectasi]

A

reverse

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64
Q

Reduced inspiratory volumes and chest wall expansion resulting from ___ ___ ___ and a reduced ___tone
[General Anesthesia causes Atelectasi]

A

deeper anesthesia depth, muscle

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65
Q

___ ___ due to artificial creation of a significantly higher A-a gradient than ___
[General Anesthesia causes Atelectasi]

A

Absorption atelectasis, normal

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66
Q

Anesthesia= FRC Decreased, Lung Compliance Decreased, Airway Resistance Increased –> Loss of tone, smaller volume, reduced ___ ___ –> ___ ___ atelectasis

[General Anesthesia and Lung Volume]

A

airway dimensions, airway closure

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67
Q

Pressure of abdominal contents and resulting FRC
Initial upright position ___
Supine position ___
Induction of anesthesia ___

A

2300 ml, 1400 ml, 950 ml

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68
Q

Atelectasis forms regardless of ___ ___

A

patient position

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69
Q

Causes of Atelectasis under General Anesthesia (3)

A

Mechanical compression
Absorption of Alveolar Gas
Surfactant dysfunction

70
Q

Mechanical Compression:
___ ___ tone reduced
___ movement cephalad

[Causes of Atelectasis under General Anesthesia]

A

Thoracic muscle, Diaphragmatic

71
Q

Absorption of Alveolar Gas:
Under-ventilated airways narrow and close.
Air in alveoli rapidly diffuses into capillary.
Alveoli ___but ___ continues.
Accelerated with ___ ___.

[Causes of Atelectasis under General Anesthesia]

A

collapses, perfusion, higher FiO2

72
Q

Surfactant dysfunction:
Positive___ and ____anesthetics

[Causes of Atelectasis under General Anesthesia]

A

pressure, volatile

73
Q

How does a high oxygen concentration cause atelectasis?

A

Accelerates alveolar absorption

74
Q

Due to oxygen’s rapid diffusing capacity
and the pressure difference across the membrane, gas is ___ ___ of the alveolus until it ___…re-opening of the ‘sticky’ atelectasis requires positive pressure of ___ cmH2O

A

‘sucked out’, collapses, 30–35

75
Q

No ___ splint and a large ___ gradient promotes ___ ___

[Delivery 100% O2, PAO2~600 mmHg, 0% Nitrogen, PaO2(v) 40, PaO2 (a) 500]

A

nitrogen, A-a, alveoli collapse

76
Q

In less than ___minutes alveoli can ___ or ___collapse.
[Delivery 100% O2 PaO2 (v) 40, PaO2 (a) 0)]

A

5, partially, totally

77
Q

___ ___remains with a reduced A-a gradient causing a ___ in alveoli collapse
[Delivery of 40% O2, PAO2 250mmHg, >50% Nitrogen, PaO2 (v) 40, PaO2 (a)200]

A

Nitrogen splint, delay

78
Q

In PACU:
Oxygen sat 92-94%, Combined with shallow respirations, from residual paralysis, residual ___/___.
Now sat drops to mid 80s
***___of pts transferred from OR to PACU without oxygen dropped their saturation to ___
[Results of 100% oxygen in OR, Unrecognized atelectasis]

A

anesthesia/opioids, 30%, <90%.

79
Q

Upper airway obstruction requiring intervention (___ ___, __ ___ or nasal airway)
[PACU Respiratory Events]

A

jaw thrust, oral airway

80
Q

Mild-moderate hypoxemia (SpO2=___ ___) on 3L NC Oxygen that was not improved after active interventions (increasing O2 flows to >3L/min, application of ___-___ ___ ___ verbal requests to ___ ___, ___ ___.)
[PACU Respiratory Events]

A

93%-90%, high-flow face mask, breathe deeply, tactile stimuli

81
Q

Severe hypoxemia (SpO2___) on 3L nasal cannula O2 that was not improved after active interventions (___ ___ ___, application of ___-___ ___ ___ verbal requests to ___ ___, ___ ___.)
[PACU Respiratory Events]

A

<90%, increasing O2 flows to >3L/min, high-flow face mask, breathe deeply, tactile stimuli

82
Q

Signs of respiratory distress or impending ___ ___ (respiratory rate ___, accessory muscle use, ___ ___)
[PACU Respiratory Events]

A

ventilatory failure, >20 bpm, tracheal tug

83
Q

Inability to___ ___ when requested to by the PACU nurse
[PACU Respiratory Events]

A

breathe deeply

84
Q

Patient complaining of symptoms of___ or ___ ____ ____ ___(difficulty breathing, swallowing or speaking)
[PACU Respiratory Events]

A

respiratory, upper airway muscle weakness

85
Q

Patient requiring ___ in the PACU
[PACU Respiratory Events]

A

reintubation

86
Q

Clinical evidence or suspicion of ___ ___ after tracheal ___ (gastric content observed in the ___ and ___)
[PACU Respiratory Events]

A

pulmonary aspiration, extubation, oropharynx, hypoxemia

87
Q

most common cause of early post op hypoxemia is ______ and ______ ______ leading to right to left intrapulmonary shunting

A

hypoventilation and lobar atelectasis

88
Q

atelectasis can remain for _____

A

days

89
Q

post op day 1 patient remains on ______ _____ at __/___

A

nasal cannula
2L/min

90
Q

post op atelectasis can show low grade _____

A

fever

91
Q

post op atelectasis - coughing up _______ _____ and CXR can show ______ infiltrates

A

yellow sputum
bilateral infiltrates

92
Q

post op atelectasis - start ______ and resp rx

A

antibiotics

93
Q

post op atelectasis may result in __-__ extra days inpatient stay

A

2-3

94
Q

these post op atelectasis symptoms are indicative of _____ _____ _____

A

postoperative pulmonary complication (PPC)

95
Q

is PPC rare?

A

no

96
Q

PPCs occur in as much as _____ of patients undergoing major non-thoracic sx

A

30%

97
Q

_______ is a locus for infection

A

atelectasis

98
Q

atelectasis and _____ account for majority of PPCs

A

pneumonia

99
Q

incidence of atelectasis following abdominal sx is as high as _____

A

69%

100
Q

PPCs are a leading cause of ______, ______, and extended ______

A

mortality, morbidity, and extended hospitalization

101
Q

we can prevent atelectasis at induction with the use of ______

A

CPAP

102
Q

CPAP has been shown to reduce atelectasis formation even if using _____ _____

A

high FiO2

103
Q

CPAP may increase _______ risk with gastric insufflation

A

aspiration

104
Q

semi recumbent vs supine: no ______ in _____

A

no reduction in atelectasis

105
Q

maintain thoracic and diaphragmatic muscle tone by (3)

A
  1. spontaneous breathing
  2. avoid paralytics
  3. ketamine use to preserve muscle tone
106
Q

there is evidence that the level of PEEP required to reopen airways may not be high enough to reopen ______ ______

A

collapsed alveoli

(may need recruitment manuever)

107
Q

PEEP of ______ with BMI < 25

A

6 cmH2O

108
Q

PEEP of ______ with BMI up to 30

A

8 cmH2O

109
Q

PEEP applied _______ _______ of atelectasis may prevent it

A

BEFORE formation

110
Q

PEEP of ______ consistently opened collapsed lung tissue

A

10 cmH2O

111
Q

_____ and ______ maintains open gas exchanging units

A

PEEP and oxygenation

112
Q

PEEP and oxygenation improves resp mechanics and oxygenation in the _____ _____

A

morbidly obese

113
Q

PEEP prevents _______ after an alveolar recruitment manuever (ARM)

A

de-recruitment

114
Q

what is a sigh breath?

A

double tidal volume breath

115
Q

with sigh breaths, amount of atelectasis is ________

A

unchanged

116
Q

single sigh breath vs sustained ARM =

A

new surfactant released

117
Q

ARM - sustained inflation with airway pressure _______

A

40 cmH2O

118
Q

ARM - 2 goals

A
  1. open airways
  2. keep them open
119
Q

ARM - sustained for __-__-__ seconds

A

7-10-15

120
Q

ARM - MUST be followed by ______ to remain open

A

PEEP

121
Q

ARM - releases ______ to alveolar wall and terminal bronchiole

A

surfactant

122
Q

avoid _____ ______

A

100% oxygen

123
Q

8 RCTs indicated that use of 100% FiO2 during GA resulted in: (4)

A
  1. accelerated atelectasis formation
  2. increased atelectatic areas of lung
  3. increased intra-pulmonary shunting
  4. worsening gas exchange
124
Q

100% FiO2 resulted in atelectasis in less than ___ ______

A

5 minutes

125
Q

5 RCTs indicated that using lower FiO2 during GA resulted in reduced _______ and ________ of absorption atelectasis

A

formation and magnitude

126
Q

atelectasis development delayed on average by as much as an hour when less than ____ FiO2 was used

A

50%

127
Q

_____ FiO2 improves gas exchange during general anesthesia

A

40%

128
Q

100% FiO2 at the end of GA promotes post op atelectasis regardless of _____

A

VCM (vital capacity manuever)

129
Q

very little atelectasis developed with ____ FiO2 after induction

A

30%

130
Q

a vital capacity manuever followed by 40% oxygen ______ _______ post op atelectasis formation

A

completely prevented

131
Q

high FiO2 is the main mechanism responsible for _______

A

atelectasis

132
Q

Multiple studies performed to assess optimal FiO2:
creating the least amount of absorption atelectasis.
Maintain ___ ___.
Maintaining acceptable ____.

A

Nitrogen splint, SaO2

133
Q

current evidence does not indicate that the possible benefits of the use of high ___ ___can overcome the detrimental consequences of postoperative pulmonary complications.”

A

oxygen concentrations,

134
Q

Ventilation during anesthesia should be done with a moderate fraction of inspired oxygen (e.g., FiO2 of ___ to ___) and should be ___ only if arterial ___ is compromised

A

0.3 to 0.4, increased, oxygenation

135
Q

Avoiding preoxygenation using 30% FiO2 eliminated atelectasis formation during ___ and subsequent ___

A

, induction, anesthesia

136
Q

FiO2 100% averaged ___-___ atelectatic lung tissue

[Preoxygenation & Atelectasis Formation]

A

15-20%

137
Q

FiO2 80% averaged __ ___ atelectatic lung tissue

[Preoxygenation & Atelectasis Formation]

A

less than 2%

138
Q

FiO2 60% nearly___ atelectatic lung tissue

[Preoxygenation & Atelectasis Formation]

A

eliminated any

139
Q

FiO2 30% = ___atelectatic lung tissue

[Preoxygenation & Atelectasis Formation]

A

no

140
Q

The final disaster…___ ___ should not be done routinely
[Oxygen at Emergence]

A

post oxygenation

141
Q

Running 100% FiO2 just prior to the end of anesthesia resulted in ___ of lung even following a ___of lung by a vital capacity maneuver
[Oxygen at Emergence]

A

derecruitment, re-expansion

142
Q

Running ___ FiO2 just prior to the end of anesthesia kept the lung open following a ___ ___ ___
[Oxygen at Emergence]

A

40%, vital capacity maneuver

143
Q

Oxygen consumption equation, VO2

A

VO2= Fi02-Fe02 x Vm /weight in kg

144
Q

O2 Content of Blood Equation

A

CaO2=(hgb x oxyhgb x 1.39)+(.003 x PaO2)

145
Q

Oxygen delivery equation

A

DO2= CaO2 (mls/dL) x CO(mls/min)/kg/100

146
Q

Does using 100% Oxygen Significantly Improve the Amount of Oxygen Delivered to the Tissues?

A

No
Assuming the patient has normal cardiac output & Hgb

Using FiO2 21% = delivers ≈ 11.7mlsO2/kg/min

Using FiO2 50% delivers ≈ 12.3mlsO2/kg/min

Using FiO2 100% delivers ≈ 13.0mlsO2/kg/min

147
Q

The ___ ____ that is the limiting factor in delivery of O2 to the tissues

[Why Does Oxygen Delivery Not Change Much?]

A

cardiovascular system

148
Q

___ is the vehicle and ____is the cargo

[Why Does Oxygen Delivery Not Change Much?]

A

Hemoglobin, oxygen

149
Q

Lower ___promotes higher ___ and O2 delivery

[Why Does Oxygen Delivery Not Change Much?]

A

Vt , CO

150
Q

If sat is near 100% then ___ FiO2 may have___effect on oxygen delivery

[Why Does Oxygen Delivery Not Change Much?]

A

increasing, little

151
Q

O2 consumption ___

[What is the Point about FiO2?]

A

3.4 mlsO2/kg/min

152
Q

Oxygen Delivery on room air: ___ (mlsO2/kg/min)
Nearly ___ more than consumed/need

[What is the Point about FiO2?]

A

11.7 mlsO2/kg/min, 4x

153
Q

No compelling reason to use ___ FIO2 unless indicated

[What is the Point about FiO2?]

A

higher

154
Q

Superphysiologic doses of blood oxygen do not result in a significant ___ in tissue ___

[What is the Point about FiO2?]

A

increase, oxygen

155
Q

Better to run slightly___sat and keep ___ ____

[What is the Point about FiO2?]

A

lower, alveoli open

156
Q

2017 WHO recommended ___FiO2 in colon surgery to reduce ___ ____ ____

[Where are We Today Regarding FiO2?]

A

high , surgical site infections (SSI)

157
Q

___guidelines generated controversy
[Where are We Today Regarding FiO2?]

A

WHO

158
Q

____Guidelines recommend ___ FiO2 for colon surgery

[Where are We Today Regarding FiO2?]

A

ERAS, high

159
Q

…___ Fio2, compared to the ___ ____ Fio2, under the perioperative conditions at this trial site does not meaningfully change clinical outcomes
[Where are We Today Regarding FiO2?]

A

80%, lowest feasible

160
Q

No Proof of ___surgical site infection in patients receiving ____ O2

[Where are We Today Regarding FiO2?]

A

reduced, 80%

161
Q

CPAP during ____/____ can ____ atelectasis formation

A

preoxygenation/induction, decrease

162
Q

____ can prevent ____ formation but use it before ____develops

A

PEEP, atelectasis, atelectasis

163
Q

___ ____ ___ recruits collapsed alveoli followed by ___to prevent reoccurrence

A

Alveolar recruitment maneuver, PEEP

164
Q

Avoid ___ ETT at emergence

A

suctioning

165
Q

Follow ___ ____ ERAS-based guidelines

A

your institution’s

166
Q

___FiO2 worsens atelectasis and ___ while less than 50% prevents atelectasis and reduces ___

A

100%, PPCs, PPCs

167
Q

Use between____and ___FiO2 during____ ____when not contraindicated

A

40%, 60%, general anesthesia

168
Q

If you must use ___ oxygen use it only with ___

A

100%, PEEP

169
Q

Emerge on less than ___ if not contraindicated

A

100%

170
Q

Pulse Oximetry does not tell the CRNA about the ___ of ___ formation

A

degree, atelectasis

171
Q

Less than ___ oxygen saturation is acceptable

A

100%