Paget's Disease of Bone Flashcards
1
Q
What is Paget’s Disease of the Bone?
A
Excessive bone turnover reabsorption and formation due to increased osteoclast and osteoblast activity leading to sclerosis and lysis
2
Q
Where does Paget’s Disease affect in particular?
A
Axial Skeleton and risk of pathological fractures
3
Q
Presentation of Paget’s?
A
Bone Pain
Bone Deformity
Fractures
Hearing Loss
4
Q
Xray findings in paget’s
A
Bone enlargement
Osteoporosis circumscripta (well defined osteolytic lesions)
Cotton wool apperance of skull
Osteoylitic defects
5
Q
Blood test results in Pagets
A
Raised Alkaline Phosphatase
Normal calcium and phosphate
6
Q
Management of Pagets
A
Bisphosphonates
NSAIDS
Monitoring
7
Q
Complications of Paget’s
A
Hearing Loss
Heart Failure
Osteosarcoma
Spinal Stenosis
