Paeds short Flashcards
KEEP IT SHORT
Rubella - urgently notifiable (within 24 hours)
Prodrome: fever, coryza, rash and lymphadenopathy
Rash: face to trunk, limb-sparing
Dx: serology rubella-specific IgM antibodies
Mx: supportive, off school until 5 days after rash develops
If unvaccinated pregnant woman: congenital rubella syndrome: cataracts, PDA, deafness
Measles - urgently notifiable
Measles morbillivirus
Prodrome: fever >40, coryza, conjunctivitis, Koplik spots (grey spots in Mouth)
2-5 days after: rash behind ears spread to trunk and limbs
Dx: oral fluid sample for measles RNA and measles-specific IgM and IgG
Mx: supportive, off school until 4 days after rash development
Complications: AOM, pneumonia, blindness, subacute sclerosing panencephalitis
Bacterial tonsillitis
Strep pyogenes (group A strep)
Centor: fever (>38), exudate, cervical lymphadenopathy, no cough
score 3/4 = abx, 1st line is Phenoxymethylpenicillin (pen V), macrolide if allergy
Pyloric stenosis
Hypertrophy of the pyloric sphincter
Key symptom: projectile vomiting post-feed
Key sign: hypokalaemic hypochloraemic metabolic alkalosis
Dx: abdominal ultrasound
Tx: IV fluids, pyloromyotomy
Status Epilepticus
Seizure > 5 mins or multiple seizures w/o regaining awareness
Mx: IV lorazepam/buccal midazolam/rectal diazepam, repeat after 10 mins if needed
Then IV Levetiracetam
Then anaesthetist or PICU
Nocturnal enuresis (bedwetting)
Primary: never been dry at night
Secondary: previously dry, now lost it (UTI, DMT1)
Dx: hx, examination, urine dip
Secondary - further Ix
Mx: avoid fluid intake before bed, regular toileting
2nd line: enuresis alarm
3rd: desmopressin (ADH analogue)
Cystic fibrosis
Autosomal recessive condition due to mutation in CFTR gene on chromosome 7
Impaired ion transport:
- Thick biliary/pancreatic/ lung secretions
- Lack of pancreatic lipase in GI, mucus excess + bacterial colonisation in lungs
Ix: newborn heel-prick, sweat test
Mx: chest physio, high-calorie diet, dornase alfa, Creon, salbutamol, prophylactic flucloxacillin
Newborns = meconium ileus
Osteosarcoma
- Malignant bone tumour, mainly affects children and adolescents.
- Clinical features: prolonged bone pain, bone swelling, decreased ROM.
- Dx: urgent X-ray within 48hrs (new bony growth - sunburnt look), CT, biopsy
- Mx: surgical resection, chemo +/= radio
Down Syndrome (Trisomy 21)
Clinical features: upward slant to eyes, single palmar crease, hypotonia, leaning difficulties, VSD/ASD
Ix: combined or quadruple test antenatally, chorionic villus sampling, amniocentesis
Mx: MDT: physio, OT, speech + language, educational support, mx of complications, regular check ups
Necrotising enterocolitis
Severe GI disease that mainly affects premature infants, intestinal ischaemia and infection
Clinical features: vomiting, bloody stools, abdo distension, acidosis
Dx: abdo x-ray shows dilated bowel loops, pneumatosis intestinalis, pneumoperitoneum
Mx: nil-by-mouth, broad-spectrum abx, Total Parenteral Nutrition , surgical resection
Acute lymphoblastic leukaemia
Uncontrolled proliferation of mutated lymphoid progenitor cells, replacing normal haematopoietic cells in the bone marrow
Clinical features: lymphadenopathy (most common), pallor, unexplained petechiae, fever, fatigue
Dx: immediate specialist referral if unexplained petechiae or hepatosplenomegaly, otherwise 48-hr FBC
Bone marrow biopsy: > 20% blast cells = diagnostic
Mx: chemo, bone marrow transplant
Neonatal jaundice
Causes: HDN, sepsis, physiological, breast milk, infection
Clinical features: yellowing of skin and eyes, poor feeding, lethargy, well if physiological or breast milk jaundice
Ix: serum bilirubin levels
Mx:
- Admit if <24 hrs or >7 days old, if unwell, <35 weeks gestational age
- Phototherapy or exchange transfusion according to treatment threshold graph
Nephrotic syndrome: minimal change disease
Peripheral/facial oedema, proteinuria, hypoalbuminemia
Dx: urine dipstick show 3+/4+ protein, urine protein: creatinine > 200mg/mmol , serum albumin < 25g/L, kidney biopsy
Mx: oral prednisolone
Immune thrombocytopenic purpura
Autoimmune disease characterised by reduced circulating platelets. Usually following a viral infection
Clinical features: easy bruising, petechiae, nosebleeds
Dx: FBC (thrombocytopenia), blood film, CRP
Mx: watch and wait as usually self-limiting
Impetigo
Staphylococcus aureus
Bullous: fluid-filled lesions > 1cm
Non-bullous: erythematous macule becoming pustules/vesicles
Dries into homey-coloured lesions
Mx:
- Hydrogen peroxide 1%
- Face: fusidic acid
- Abx e.g. flucloxacillin (or clarithromycin) if widespread or bullous
- Stay off school until 48 hours after tx started
Pertussis (whooping cough)
Bordetella pertussis - gram -ve coccobacillus
Clinical features: flu-like, coryza, fever for 1-2 weeks, then intense “whooping” cough fits, maybe vomit, faint or cyanosis after. Young infants: apnoea, no whoop
Dx: PCR + culture of nasopharyngeal swabs or secretions
Mx: < 21 days onset e.g. clarithromycin, admission if <6m or resp complications
Preorbital cellulitis
Infection and inflammation of the superficial tissue around the eyes
Clinical features: erythema, swelling, pain, fever, malaise
Mx: immediate empirical oral/IV abx based on severity e.g. flucloxacillin
Infectious mononucleosis (glandular fever)
Epstein Barr virus, transmitted via saliva
Clinical features: fever, sore throat, fatigue, hepato/splenomegaly
Dx: clinical, +ve heterophile antibody (Paul Bunnell) test
Mx: maculopapular rash if treated with amoxicillin otherwise supportive
Parvovirus B19 infection (slapped cheek syndrome/5th disease)
Prodrome: fever, coryza, and diarrhoea
Then reticular (lace-like) rash across body and bright red cheeks . Perioral and forehead-sparing
Dx: clinical
Mx: supportive, children can go back to school when rash appears as no longer infectious
Can cause hydrops fetalis (oedema) in foetus and aplastic crisis in sickle cell anaemia
Non-accidental injury
Clinical features: delayed presentation, inconsistent caregiver history, injuries/bruises at various healing stages, unwitnessed injury, subconjunctival/retinal haemorrhage
Dx: detailed hx, body map and skeletal survey
Mx: inform senior or safeguarding lead, admit for safeguarding while investigations, treat wounds, social service involvement
Juvenile idiopathic arthritis
Common paediatric chronic inflammatory joint condition
Persistent joint swelling > 6 weeks before 16yo without infection/other causes
Clinical features: salmon pink rash, fever > 5 days, malaise, joint pain
Dx: negative antinuclear ab and rheumatoid factor, raised CRP
Mx: MDT: paeds, physio, OT, ophthalmologists, NSAIDS, intra-articular (if only affecting a few joints) or oral steroids (systemic disease) for flares e.g. methylprednisolone
Neonatal respiratory distress syndrome
Deficiency of surfactant in lungs = alveolar collapse
Preterm infants < 35weeks
Clinical features: respiratory distress: tachypnoea, nasal flaring, grunting and intercostal recession
Ix: X-ray: ground-glass appearance = oedema in alveoli
Mx: if preterm birth suspected, maternal corticosteroids to help foetal surfactant production
Neonate: Intratracheal artificial surfactant
Duchenne muscular dystrophy
Most common type of muscular dystrophy, X-linked recessive (boys)
Clinical features: muscle wasting, weakness, difficulties with movement, hypertrophic calves
Gower’s sign: use hands to climb up the legs when rising from floor
Dx: creatinine kinase, then genetic testing
Mx: MDT, exercise, physio, wheelchairs, mobility aids, glucocorticoids, genetic counselling
Meningococcal infection - notifiable
Neisseria meningitidis
Clinical features: fever, lethargy, headache, rigors, vomiting, non-blanching purpuric rash, hypovolaemic shock
Dx: blood culture, CSF
Mx: DO NOT DELAY empirical IV abx, then treat based on sensitivities and local guidelines
<3 months = cefotaxime
> 3 months = ceftriaxone
Ciprofloxacin for close contacts
Type 1 diabetes mellitus
Destruction of insulin-producing beta-cells in the pancreas
Clinical features: polydipsia, polyuria, lethargy, weight loss
Dx:
- Oral glucose tolerance test > 11.1mmol/L
- Random BM > 11.0mmol/L
- Fasting BM > 7.0mmol/L
- HbA1c: >6.5% or 48 mmol/mol)
Mx:
Basal-bolus insulin regime - long-acting at night and short-acting before meals
Hypo: sugary snack if conscious, IV dextrose/IM glucagon if unconscious
Neonatal sepsis
Severe infection in infants < 90 days
Early onset within 72 hrs of life - Group B Strep (S. agalactiae)
Late-onset after 72 hrs - Staph. aureus
Clinical features: feeding difficulties, fever, respiratory distress, reduced GCS
Dx: FBC, CRP, blood cultures, LP for meningitis, CXR for meconium aspiration. Add urine sample if late onset
Mx: early onset = empirical IV benzylpenicillin and gentamicin, then based on culture results
Late onset = broad spectrum (IV flucloxacillin + gentamicin)