Paeds endocrinology Flashcards

1
Q
  • Describe type 1 diabetes pathophysiology briefly
A
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2
Q

Ketogenesis occurs when

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3
Q
  • Type 1 diabetes presentation
A
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4
Q

When a new diagnosis of type 1 diabetes is established the following bloods should be taken to exclude other associated pathology and get a baseline idea of the child’s overall health:

A
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5
Q
  • Long term management of diabetes involves:
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6
Q

Insulin is usually prescribed as a combination of

A
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7
Q

Injecting insulin into the same spot repeatedly can cause a condition called

A
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8
Q

Insulin regimes are initiated by a specialist in diabetes. Patients are usually initiated on a… regime.

A

Insulin regimes are initiated by a specialist in diabetes. Patients are usually initiated on a basal-bolus regime.

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9
Q

what is a basal bolus insulin regime

A
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10
Q
  • What are insulin pumps and how do they work?
A
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11
Q

To qualify for an insulin pump funded by the NHS the child needs to

A

To qualify for an insulin pump funded by the NHS the child needs to be over 12 and have difficulty controlling their HbA1c. Local criteria may vary.

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12
Q
  • Advantages and disadvantages of an insulin pump
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13
Q
  • There are two types of insulin pump:
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14
Q

Short term complications relate to immediate insulin and blood glucose management:

A

Hypoglycaemia
Hyperglycaemia (and DKA)

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15
Q

In diabetes, hypoglycaemia is caused by:….symptoms of hypoglaecemia are:

A
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16
Q

Hypoglycaemia needs to be treated with

A
17
Q

Other causes of hypoglycaemia include

A

hypothyroidism
glycogen storage disorders
growth hormone deficiency
liver cirrhosis
alcohol and fatty acid oxidation defects (such as MCADD).

18
Q
  • Nocturnal hypoglycaemia is..it’s treated by
A
19
Q
  • How to treat patients with hyperglycaemia
A
20
Q
  • Long term complications of hyperglycaemia
A
21
Q
  • How is blood glucose monitored in diabetes
A
22
Q
  • How often is HbA1c measured in diabetes
A

every 3 to 6 months

23
Q

Ketogenesis normally occurs when

A
23
Q
  • Ketone levels can be measured how?
A

Ketone levels can be measured in the urine using a** urine dipstick** and in the **blood **using a ketone meter.

23
Q
  • People in ketosis have a characteristic
A

People in ketosis have a characteristic acetone smell to their breath.

24
Q

hen underlying pathology (i.e. type 1 diabetes) causes extreme hyperglycaemic ketosis, this results in

A
24
Q
  • Pathophysiology of DKA
A
24
Q

Presentation of DKA

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24
Q

…should be monitored very closely (e.g. hourly) to look for signs of cerebral oedema. Signs include:

A
24
Q

Children with DKA are at high risk of developing

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25
Q

Management options for cerebral oedema

A

Management options for cerebral oedema are slowing IV fluids, IV mannitol and IV hypertonic saline. These should be guided by an experienced paediatrician.

26
Q

Diagnosing DKA

A
27
Q

most common cause of hypothyrodism in children in the UK

A