Paediatrics Flashcards
Paediatric Ketamine Sedation
EM Rapid Bombs ep 61 - ketamine side effect
sedative
analgesia
dissociative
preserves upper airway reflexes
emergence phenomenon is the most common adverse effect
IV Ketamine
1-2mg/kg
subsequent incremental doses 0.5mg/kg
slow IV push over 1-2min. rapid push associated with respiratory depression.
Advantage - ease of repeat dosing, faster recovery
Clinical onset - 1 min
Effective sedation - 10min
Time to discharge - 60min
IM Ketamine
3-4mg/kg
a repeat dose of 2-4mg/kg can be given after 10min
ketamine can be safely used without IV access
Advantage - no IV necessary
Clinical onset - 4mins
Effective sedation 20min
Time to dischage - 2hrs
SIDE EFFECTS:
Transient tachycardia and hypertension
Laryngospasm (0.3%)
Emergence phenomena - recover in quiet low stimulus environment
Vomiting - prophylactic ondansetron
Hypersalivation
Nystagmus
Apnoea and respiratory depression - if given too rapidly
Muscle twitching and purposeless movements
CONTRAINDICATIONS:
Absolute:
allergy
< 3months
schizophrenia
Relative:
current respiratory illness
known difficult airway
procedures that will stimulate oropharynx
age 3-6 months
VOMITING & LARYNGOSPASM:
1) Stop the procedure.
2) Call for help. Children become hypoxic quickly.
Gentle suction of vomitus under direct vision
3) 100% oxygen BVM maximum PEEP and tight seal
- Attempt manual two persons BVM ventilation
4) try to break the laryngospasm with Larsons manouvre + jaw thrust.
(firm pressure on posterior ramus of mandible)
5) If not able to adequately manually ventilate –> Deepen anaesthesia with propofol 1-2mg/kg IV
–> give suxamethonium 1-2mg/kg and intubate
(IM suxamethonium 3-4mg/kg if no IV)
atropine 20mcg/kg for bradycardia
RATIONALE FOR FASTING
1) Most guidelines state that patients should be fasted for 4-6 hours prior to procedural sedation.
2) Aspiration is not impossible with ketamine, if it is not an emergency procedure - best to wait until fasted
RATIONALE FOR PROCEEDING WITHOUT FASTING
1) Medical emergency e.g. neurovascular compromise of a displaced fracture outweighs the risk of aspiration
2) there is no relationship between adverse respiratory events and fasting times in any studies thus far
3) Maintain airway reflexes with ketamine
Paediatric Procedural Sedation
weight = age + 4 x2
ETT = age/4 + 3.5 (cuffed ETT)
Bridging analgesia:
- fentanyl 1.5mcg/kg IN
Family involvement:
- support child, reduce anxiety
- help with distraction
PREPARATION:
Airway assessment:
Previous sedation/anaesthesia
Fasted for non-emergent procedures
Current illness - URTI
PMHx:
Medications:
Allergies:
Equipment:
- suction
- oxygen
- bag valve mask
- OPA, NPA
- monitoring
Drugs:
- ketamine 1-2mg/kg IV
- Premedication with ondansetron to reduce risk of vomiting
Paediatric Head Injury
2022.1 Case Based Discussion Station
8yr old with head injury after falling at a playground
Explain how you would decide if the child would need a CT scan
Patient deteriorates and is combative. Discuss Intubation vs sedation for CT.
Interpret CT scan and outline management
PECARN identify patients at very low risk of intracranial injury who do not need a CT scan (all predictor variables negative, no CT required)
PECARN the only prospectively validated decision making rule
PECARN has highest sensitivity in ruling out serious pathology
It helps us to balance the risk of missing a significant injury, and to minimize the risk of radiation-induced cancer in the paediatric population
AGE <2yrs
GCS <14
Altered mental status
Loss of consciousness
Parietal, temporal, occipital haematoma
Not acting normal as per parent
Severe mechanism:
- MVC with patient ejection,
- death of another passenger
- rollover
- pedestrian or bicyclist w/o helmet struck by motorized vehicle;
- fall from >0.9m
AGE >2yrs
GCS<14
Signs of base of skull fracture (racoon eyes, battle sign)
Altered mental status
Intractable vomiting
Severe headache
Dangerous mechanism
- fall >1.5m
MODIFIED PAEDIATRIC GCS:
alteration in verbal response
coos or babbles = 5
irritable cry = 4
cries to pain = 3
moans to pain = 2
no response = 1
If PECARN negative:
CT is not required as per best practice evidence
The purpose of non-con CT brain is to detect critical intracranial injuries that require urgent neurosurgical intervention
Risk associated with procedural sedation required to obtain the CT scan - aspiration, respiratory depression
Radiation exposure increases lifetime risk of developing brain cancer
1: 1500 in 1yr
1: 10,000 10yr old
Concussion will reveal a normal CT scan and is managed conservatively
Paediatric Head Injury
2023.2 History taking station
Take a focused history from a parent (role player) of a paediatric patient with a head injury.
After assessment.
The patient does not require CT brain.
Outline your management plan.
Tips:
- Consider non-accidental injury
- Assess cervical spine
HISTORY:
Mechanism:
- when
- how
Red flag symptoms:
- abnormal behaviour
- drowsy/lethargic
- irritable
- headache
- scalp haematoma
- blood coming from ears (haemotympanum)
- clear liquid coming from ears or nose (CSR rhinorrhoea)
- bruising behind ears (battle sign)
- memory impairment
- loss of consciousness
- seizures
- difficulty walking
- intractable vomiting
- other injuries sustatined
RED FLAGS FOR CHILD ABUSE:
PMHx:
- bleeding disorders (haemophilia)
- VP shunts
- Neurodevelopmental disorders (autism) - difficult to assess –> lower threshold to CT
Meds:
IMMUNISATIONS:
ALLERGIES
SOCIAL:
- where do you live
- who lives at home
- access to medical services, car, phone
EXAMINATION:
Scalp haematomas
- high risk if occipital, parietal and temporal as opposed to frontal
- boggy suggestive of skull fracture
Signs of base of skull fracture:
- battle sign
- raccoon eyes
- CSF otorrhoea/rhinorrhoea
- haemotympanum
Assess for signs of raised ICP and brain herniation:
- reduced LOC
- blown pupil
- hemiparesis
- abnormal posturing (decorticate or decerebrate)
- cushings reflex (bradycardia, hypertension)
ASSESSMENT OF CERVICAL SPINE
MANAGEMENT:
- Child with head injury is a very common presentation to the emergency department. It is something that we see and treat a lot.
- The next step in my assessment is to decide whether or not we need to do a CT scan of the head.
- We perform CT scans to looks for serious injuries to the brain that need urgent treatments. For example a bleed on the brain.
- As you may be aware, CT scans are not completely benign tests. They do expose the growing brain to radiation which does increase the lifetime risk of developing brain cancer. This risk is higher the younger the child.
1: 1500 in 1yr old
1: 10,000 10yr old
We use a clinical decision tool to help us identify which patients need to have CT.
This tool helps us to balance the risk of missing a serious brain injury, and to minimise radiation induced cancer in the paediatric population.
Based on the information that I have gathered today. Your risk of having a serious injury inside your head is very low. Almost negligible. <0.05%.
Therefore we will not proceed to a CT scan. We will observe you for 6hrs from the time of injury.
Head Injury Intubation
Prevent raised ICP - raise head of bed 30 degrees
Anticipate difficult intubation due to potential c-spine injury/in line immobilisation
Blunt sympathetic response from laryngeal manipulation - pre medication with fentanyl 1mcg/kg IV (need to give this 3-5min before induction)
Ketamine 1-2mg/kg for induction - haemodynamically stable
Rocuronium 1.2mg/kg IV
Avoid hypotension:
have vasopressors on stand by
adrenaline 1mcg/kg IV Q5min
adequately fluid resuscitate before induction
Avoid hypoxia - pre-oxygenate with high flow oxygen 15L NRBM
Treat raised ICP:
- 3% NS 3-5ml/kg IV following by infusion 0.1ml/kg/hr to maintain Na+ 155-165
OR
- Mannitol 0.5–1 gram/kg
Maintain SaO2 >90%, PCO2 35-40
Maintain normothermia 36-37
Maintain normoglycemia - check BSL Q1h - especially important in paediatric patients
Maintain SBP >70 + (age x2)
Invasive BP monitoring with arterial line
adrenaline infusion 0.05-1mcg/kg/min
Seizure prophylaxis:
levetiracetam 15-40mg/kg IV
Immediate Neurosurgical attendance to facilitate decompressive craniectomy
BRAIN HERNIATION
BRAIN HERNIATION:
uncal herniation:
- compression of the occulomotor nerve –> ispilateral fixed dilated pupil
- contralateral hemiparesis
Central transtentorial herniation:
- bilateral pin-point fixed pupils
- bilateral babiski
- increased tone
- progress to hyperventilation and decorticate posturing
Cerebellotonsillar herniation:
- flaccid paralysis
- bradycardia
- respiratory arrest
- sudden death
Paediatric Asthma
Escalate oxygen therapy - High flow nasal prongs, flow rate 2ml/kg, FiO2 100%
Continuous nebulised salbutamol 2x 5mg undiluted vials
add nebulised ipratropium 500mcg every 20min (3 doses)
IV access - blood gass
Methylprednisone 1mg/kg IV
Magnesium 0.2mmol/kg (max 8mmol) IV over 20min
Aminophylline 10mg/kg IV over 1hr
Salbutamol 5mcg/kg/min for 1hr
Request portable chest xray
c)
Use the largest tube possible.
Use lowest FiO2 to achieve SpO2 of 90-92%
Use a small tidal volume, 5-7ml/kg
Use a slow respiratory rate, 8 breaths per minute
Use a long expiratory time, with I:E ratio 1:4
Increase inspiratory flow rate to maximum 60-80L/min
Reset the pressure limits (i.e. ignore high peak airway pressures). .
Use heavy sedation.
Use neuromuscular blockade.
Use minimal PEEP 0cmH2O
Keep the Pplat below 25cmH2o to prevent dynamic hyperinflation.
Post Intubation Deterioration in Asthma - Assessment and Management
POST INTUBATION DETERIORATION
1) Disconnect the ETT from the ventilator and decompress the chest
- breath stacking causes dynamic hyperinflation, decreased venous return causing hypotension
2) Use BVM with CO2 capnography to ventilate. Slow ventilation RR 5/min, TV 5-7ml/kg. Can feel lung compliance. This can also rule out EQUIPMENT FAILURE.
3) Assess for TENSION PNEUMOTHORAX
trachea deviated to one side?
chest asymmetry?
auscultation and percussion findings?
proceed to needle decompression and chest tube placement.
Hypovolemia - fluid bolus 20ml/kg 0.9%
Anaphylaxis to induction agents/sedation - adrenaline infusion 0.05-1mcg/kg/min
Excess sedation - especially propofol and fentanyl - reduce sedation infusion rate, consider changing sedation or add a adrenaline infusion
Sepsis - vasopressors + antibiotics
Bronchospasm
Paediatric Asthma
2022.1 Teaching Station
Dx: Moderate Asthma for discharge home. Teach parent to use spacer and give discharge advice
SAFE FOR DISCHARGE CRITERIA:
- no oxygen requirement
- no increased work of breathing
- normal behaviour
- bronchodilator stretched to 3hrs
- proper spacer technique
- understand return advice
- safe discharge location
- written asthma action plan
- follow up arranged
DISCHARGE ADVICE
EDUCATION:
- assess knowledge and understanding and address gaps on
symptom recognition and management
WARNING SIGNS OF WORSENING ASTHMA - SEEK MEDICAL REVIEW ASAP
- Night time coughing or wheezing
- Unable to participate in usual activities without wheezing, coughing, or becoming short of breath
- Needing to use reliever medicine every 3-4 hours
- when to seek medical attention
emergency management
WHEN TO CALL AN AMBULANCE
- Needing to use reliever more frequently with no relief
- Child is distressed and anxious
- Child is sucking in at the throat and ribs when they breath
- Child has a bluish tinge to the lips
- Child is unable to talk due to breathlessness
- If you have concerns or doubts
ROLE OF RELIEVER AND PREVENTER THERAPY:
Reliver - relaxes the muscles encircling the airways to allow them to open
Preventer - reduces airway inflammation preventing exacerbations. must be used morning and night. rinse mouth or brush teeth to prevent oral thrush.
INHALER TECHNIQUE: See video
CLEANING SPACER:
Take the spacer apart if possible.
* Wash in warm soapy water (dishwashing liquid).
* Allow the parts to air dry. Rinsing and drying with a cloth may cause static electricity to build up resulting in the medication clinging to the inside of spacer.
* When dry put spacer back together ready for use.
TRIGGERS:
- cigarette smoking
- thunderstorms
- exercise
- dust and pollen
- cats, dogs
Always carry preventer and spacer
FOLLOW-UP:
Follow-up organised with GP
Discharge letter to GP
ASTHMA ACTION PLAN:
Complete course of oral steroids
Give 4 puffs salbutamol
If no relief after 4min, give a further 4 puffs
If no relief, call ambulance and continue giving 4 puffs every 4min until ambulance arrive
Refer to educational videos
Given written information - asthma education pack
Bronchiolitis
2022.1 Station
REASONS FOR ADMISSION:
- oxygen requirement
- marked increased work of breathing with potential need for positive pressure ventilation / NIV
- poor feeding requiring NGT placement (<50% normal intake with evidence of dehydration)
- early in illness i.e. day 1 with potential to deteriorate
- risk factors for severe bronchiolitis:
- premature baby
- <6wks old
- low birth weight/failure to thrive
- lung disease e.g. Cystic fibrosis
- congenital cardiac disease e.g. Tetralogy of fallot,
- immunecompromised
Paediatric Seizures
Seizure characteristics:
- Lateralized tongue-biting (high specificity)
- Flickering eye-lids
- Dilated pupils with blank stare
- Lip smacking
- Increased heart rate and blood pressure during event
- Post-ictal phase
Seizure mimics:
- breath holding spells (emotional trigger, 6-18months, quick recovery)
- pseudoseizure (more in adolescents)
- syncope (quick recovery)
Who needs CT scan:
- concerns about non-accidental injury
- altered mentation, focal neurology
- signs of raised intracranial pressure and brain herniation
- history of hydrocephalus with VP shunt
Simple febrile seizures:
- 6 months to 6 years
- occur early in febrile illness
- generalised tonic-clonic
- duration <15min
- recovery to baseline within 1hr
- does not recur within 24hrs
- no greater risk for
serious bacterial infection (bacterial meningitis) than age-matched controls who have not seized - treat as normal febrile illness
- if benign febrile illness, can discharge home with counselling
Complex febrile seizures:
- focal seizures
- duration >15min
- incomplete recovery within 1hr
- multiple seizures in 24hrs
Need to further work up to exclude more sinister pathology:
(bacterial meningitis, NAI and brain injury)
- bloods and urinalysis
- consider CT brain and LP
Counselling Parent - Febrile Seizure
Febrile seizures are common
1 in 30 children will have a febrile seizure
Usually happens between age 6 months - 6 years
Treating a child’s fever with paracetamol or ibuprofen will not prevent a febrile seizure.
Febrile seizures do not cause brain damage, and there is no increased risk of epilepsy in children who have had simple febrile seizures.
Risk of recurrence is approximately 33% overall with a higher risk
in children
*<18 months of age
* temperature < 40.0°C at first convulsion
* <1hr between onset of fever and first seizure
* family history of febrile seizures
WHAT TO DO:
- stay calm, seizure will stop on its own
- Place your child in recovery position on on a soft surface
- don’t put anything in mouth
- don’t restrain
- don’t place in cold bath
- watch what happens so you can describe to doctor
- time how long seizure lasts
WHEN TO CALL AMBULANCE:
- seizure lasts >5min
- does not wake up after seizure
- looks very unwell or you are concerned
KEY POINTS:
- One in 30 children have a febrile seizure, usually between the ages of six months and six years.
- Nothing can be done to prevent a febrile seizure from occurring.
- During a seizure, remain calm and try not to panic.
- Do not put your child in a bath, restrain them, or put anything in their mouth.
- Febrile seizures are not harmful to your child, and will not cause brain damage.
- If the seizure lasts more than five minutes call an ambulance.
Status Epilepticus
2023.1 Case based discussion
5 month old with status epilepticus
- not febrile
- outside the age for febrile convulsions
Differential Diagnosis:
Metabolic derangement:
- hypoglycemia (congenital adrenal hyperplasia, inborn errors of metabolism)
Electrolyte disturbance:
- hyponatremia (dilute formula, congenial adrenal hyperplasia)
Infection:
- meningitis
- encephalitis
Trauma:
- non-accidental injury
- head injury
Neurological:
- malignancy
- hydrocephalus
- raised intracranial pressure
Toxicological:
- Na+ channel blockers (TCA, fleicanide, propanolol)
Haematological:
- Haemophilia A spontaneous intracranial haemorrhage
- sickle cell disease causing stroke
MENINGITIS:
dexamethasone
- blunts the inflammatory response in bacterial meningitis, reduction in mortality
- reduce the rate of neurological complications such as hearing loss
Cefotaxime - H. influenza, S. pneumoniae, N. meningitidis are sensitive to cefotaxime
Receives Hib and pneumococcal vaccine at 2 and 4 months of age, but meningicoccal is not until 12 months
INVESTIGATION:
VBG - Na+, glucose
FBC - leukocytosis, leukopenia in sepsis
CRP
MANAGEMENT:
calculate estimated weight
= (age + 4) x2
= 8kg
High flow oxygen 15L NRBM
jaw thrust +/- nasopharyngeal airway
IV or IO access
Check BSL
<2.6 give 2ml/kg 10% dextrose IV/IO
aim BSL >4
Midazolam 0.2mg/kg IV/IM
Midazolam 0.3mg/kg buccal/IN
Repeat Midazolam 0.2mg/kg IV
2nd line agents:
- Levitiracetam 40mg/kg IV over 5min
- Phenytoin 20mg/kg IV over 20min
- Phenobarbitone 20mg/kg over 20min
3rd line:
RSI + Intubation
Propofol 2mg/kg IV
Rocuronium 1.2mg/kg IV
Post intubation sedation with midazolam infusion 1mcg/kg/min
Give dexamethasone 0.15mg/kg IV and ceftriaxone 50mg/kg IV to cover for meningitis
Treat hyponatremia with 3% hypertonic saline 3-5ml/kg IV (100ml) over 10min, repeat max 3 infusions
aim to raised Na+ by 4-6mmol/L
ASSESSMENT (potential causes and complications)
ASSESSMENT:
SKIN:
- pigmentation in CAH
- cafe au lait spots (neurofibromatosis)
- ash leaf spots (tuberous sclerosis)
- port wine stains (sturge weber syndrome)
- petechiae in bacterial meningitis or haemophilia
- injuries consistent with non-accidental injury
HEAD:
- scalp haematomas
- bulging fontanelles (raised ICP)
- VP shunt
EYES:
- papilloedema
- retinal haemorrhages
- subconjunctival haemorrhages
Hepatosplenomegaly - glycogen storage disease
COMPLICATIONS:
- aspiration
- trauma
- hyperthermia
- rhabdomyolysis and renal failure
- non-cardiogenic pulmonary oedema
INVESTIGATIONS:
BSL
VBG - metabolic acidosis, respiratory failure, Na+, Glucose
Renal function and electrolytes
CK (rhabdomyolysis)
ECG - QRS prolongation, terminal R wave in aVR, arrythmias
CT brain - cerebral oedema, intracranial haemorrhage, tumour, hydrophephalus, stroke in sickle cell disease
CXR - check ETT placement, aspiration, non-cardiogenic pulmonary oedema
If suspect NAI:
Meticulous documentation
Mandatory reporting to child protective services
Paediatric Hypoxia and Shock
2021.2 modified simulation
Differential diagnoses:
- status asthmaticus
- tension pneumothorax
- anaphylaxis
- pneumoniae with sepsis
- cardiomyopathy with pulmonary oedema
- myopericarditis with tamponade
Trauma - non-accidental injury
Haemorrhagic shock
Toxicological -
Child deteriorates and requires intubation:
- outline intubation plan
Weight = (Age + 4) x2
ETT = (Age/4) + 3.5 cuffed
High risk features on assessment:
- tachycardia
- hypotension is a late sign
- peripherally shut down, cool peripheries, slow capillary return
- altered mentation
Causes of difficult ventilation:
- tube displacement (check correct placement - ET CO2, CXR
- obstruction (suction tube)
- bronchospasm (salbutamol3x 5mg nebs, ipratropium 3x 250mcg nebs, IV magnesium 40mg/kg IV over 20min)
CAUSES:
ETT displaced/cuff not inflated
Obstruction of ETT/Bronchospasm
Pneumothorax
Equipment malfunction (disconnection of the ventilator, incorrect vent settings, etc.)
Stacking (breath stacking)
STATEGIES:
Disconnect from ventilator, BV tube and feel resistance as you bag
Suction ETT, check for kinks, inadvertent extubation
Treat brochospasm
- salbutamol 15mg/hr nebs
- ipratropium 250mcg nebs q20min
- magnesium 40mg/kg IV over 20min
Check ventilation settings
POCUS - pneumothorax
- absent lung sliding
- absent comet tails
- lung point
MANAGEMENT:
Statement that child is critically unwell in a shocked state
Transfer to resuscitation room and call for senior help
Oxygen:
Respiratory support with HFNP 2ml/kg FiO2 100% target
(positive pressure ventilation will worsen hypotension)
IV access, early IO if no access in 2min
2x tibial IO - one line for fluids, one line for antibiotics
Aggressive fluid resuscitation - 3 X 20ml/kg 0.9% NS IV within the first hour of resuscitation
Urgent antibiotics:
Antibiotics for pneumoniae
ceftriaxone 50mg/kg + flucloxacillin 50mg/kg (to cover for staph aureus pneumoniae)
Vasopressors for fluid refractory shock:
adrenaline infusion
- 6mg 1 in 1000 in 1L 0.9% NS
1ml = 0.1mcg
start infusion at 1ml/kg/hr and titrate up to 10ml/kg/hr
target MAP 70
ASSESSMENT:
- assessment will be happening concurrently with resuscitation
Involve parents - collateral history
Bloods:
- VBG
- FBC (leukocytosis, leukopenia)
- UEC & LFT’s (end organ perfusion)
- CRP
- Blood cultures
Place IDC and obtain urine sample for microscopy and culture
Portable CXR
POCUS
- pneumothorax
- pericardial effusion
- pulmonary oedema
- abdominal free fluid
- guide fluid resuscitation with regular assessment of IVC
- may aid in securing IV line
INTUBATION:
- high risk of cardiac arrest in children with septic shock
- most of the medications for induction will worsen hypotension
- even ketamine will cause hypotension in children who are catecholamine depleted
- need to assess whether intubation is truly indicated
- need to optimise and prepare for safe and controlled intubation
Pre-oxygenated
Fluid resuscitated
Vasopressors infusing
Induction with ketamine 1mg/kg IV
Paralysis with rocuronium 0.6-1.2mg/kg IV
post intubation sedation
central venous catheter placement
monitor UO aim 30ml/kg/hr
Q1h VBG - lactate, glucose
consider hydrocortisone 2mg/kg IV in fluid and vasopressor resistant shock
EARLY INVOLVEMENT PAEDIATRICS/ICU/RETRIEVAL SERVICES
Consider ECMO
Departmental paediatric sepsis protocols and algorithms
Paediatric Button Battery Ingestion
2023.2 teaching station
Teach a junior doctor on the assessment and management of a child with a suspected ingested foreign body.
If battery passed into stomach.
consideration of endoscopic assessment and removal in:
patients <5 year old OR
the battery is > 2cm in diameter
Life threatening situation
If not detected and managed early has significant mortality and morbidity.
If a parent thinks the child swallowed a coin – assume button battery ingestion until proven otherwise.
More damage with 3V lithium batteries >2cm
Impactions in the proximal and mid oesophagus are most dangerous.
CHEMICAL BURN:
Caustic chemical reaction – this leads to an alkaline burn and liquefactive necrosis through the oesophagus, trachea, and major blood vessels
- tracheoesophageal fistula
- aortoesophageal fistula
TIME is oesophagus:
*Necrosis starts within 15min of ingestion
*The risk of perforation increases dramatically after 12 hours
*Need to have button battery removed within 2hrs to avoid serious injury
PRESENTATION:
Often vague and nonspecific
hx of coaching event
witnessed ingestion
- if parent says that child swallowed a coin is a button battery until proven otherwise
- cough
- chest pain
- wheeze
- vomiting
- hematemesis
- poor feeding/food refusal
- fever
Xray neck and chest (AP and Lateral)
- halo sign seen on AP
- step off sign seen on Lateral
MANAGEMENT:
neutralising agent - sucralfate or honey
can only give this within 12hrs of ingestion as risk of perforation increases after 12hrs
reducing pH and coating the battery to delay alkaline burns to tissue
Honey dose: 2 teaspoons (10 ml) of honey every 10 minutes up to 6 doses
OR
Dosing sucralfate: 1g (10 ml) every 10 minutes up to 3 doses
Needs endoscopic removal