Paediatric Gastroenterology Flashcards
Diagnosis 4-12 wk old presenting with projectile, non-bilous vomiting?
Pyloric stenosis
What is the vomit like in PS?
White curd-like
What are other symptoms of PS?
Weight loss
Not feeding
Shock
DEHYDRATION
Investigation for PS?
Test feed
- Examing abdomen that distends as it reaches pylorus
- USS
- Bloods
- Blood gases
What will be seen on USS in PS?
Long thickened pylorus
What blood gas results will be seen in PS?
Metabolic alkalosis
What may be seen on bloods in PS?
Hypochloreamia
Hypokalaemia
Treatment PS?
Fluids replacement
Pyloric myotomy
3 causes of effortless vomiting?
Relaxation in LOS
Hiatus hernia
Neuromuscular disorder
What is sanifer’s syndrome?
Spastic torticollis
Dystonic movements
Investigation for effortless vomiting?
Barium swallow if dysphagia
Gold standard = pH study
Management of effortless vomiting?
Thickened feed
Oral stimulation
Exclusional diet if support fails - may be sensitivity
NG feeding - serious
What surgery can be done for effortless vomiting if it is causing failure to thrive or aspiration?
Nissen fundoplication
What is CMPA?
Cow’s milk protein allergy
% of CMPA?
2-5%
What does not mediate CMPA?
IgE
What is thought to mediate CMPA?
T cells
What are the symptoms of CMPA?
Slow developing Over hours and day Diarrhoea and vomiting Poor feeding Reflux
Failure to thrive
What symptom may be present if it is IgE CMPA?
Eczema
Investigation for CMPA?
Exclusion trial diet for 6 months (mother)
Treatment for CMPA?
Formula - extensively hydrolysed formula
Exclude cows milk from mothers diet
Dietetics referral
Calcium supps
What can be tried at 6 months or 1year?
Milk challenge
- Baked milk
- Cooked milk
- Yoghurt
- Solids
- Normal milk
What are the symptoms of an IgE allergy?
Reaction within 2 hours Urticaria Angiodema Pruritis Conjunctivitis Wheeze/stridor
Anaphylaxis
What are causes of BILOUS vomiting?
Intestinal atresia Malrotation causing a volvulus Intussiception Ileus Crohns - strictures
What is green vomit always caused by?
Pathology
What is investigation for bilous vomiting?
AxR
- Intussiception = target sign
Contrast meal
Surgical opinion
What are causes of chronic constipation/soiling?
Poor diet Bad potty training Illness Medication Psychological
What can chronic constipation lead to/withholding
Bowel impaction
- Large hard stool
What are signs of bowel impaction?
Diarrhoea - watery
Treatment of bowel impaction?
Laxatives high dose
Fluids
Totally empty colon then slowly wean off treatment
Investigations of chronic constipation?
History
AxR if red flags
3 types of laxatives?
Osmotic - lactulose
Stimulant - senna
Isotonic - movicol
Treatment of Crohns?
5-ASA
Azothioprine
Methotrexate
Infliximab
What are the 3 main causes of diarrhoea in kids?
MOTILITY DISTURBANCE
SECRETORY
OSMOTIC/MALABSORPTIVE
What are the motility disturbance causes of diarrhoea?
IBS
Toddler diarrhoea
What are the secretory causes of diarrhoea?
Infection
IBD
Congenital hypothyroidism
What are the osmotic/malabsorptive causes of diarrhoea?
CF
Chronic liver disease (lack of bile)
Coeliac
Food allergy
What is the pathology of secretory diarrhoea?
Driven by Cl- CFTR channels
What is the pathology of osmotic diarrhoea?
Movement of water across the bowel to equalise equilibrium
What is a red flag in the history?
Nocturnal defecation
Define acute
<1 week
Define persistent
2-4 weeks
Define chronic
> 4 weeks
More than 4 stools per day
Investigation for diarrhoea?
Faeces analysis
- Define type of diarrhoea
What will faeces analysis show with secretory diarrhoea?
Large volume
Continues with fasting
What will faeces analysis show with osmotic diarrhoea?
Small volume
Stops with fasting
What genes cause coeliac?
HLA - DQ2/DQ8
What is coeliac?
Gliadin sensitivity
Investigations coeliac?
Anti - TTG
Anti-endomysial
Duodenal biopsy
What may cause false positive anti-TTG?
IgA deficiency
What should be tested if IgA is low?
Anti-endomysial Ab
What levels of anti-TTG mean a duodenal biopsy is unnessesary?
10x normal with normal IgA
Tx coeliac?
Gluten free diet for life
What does untreated coeliac increase risk of?
Small bowel lymphoma
What would be seen on duodenal biopsy in coeliac?
Crypt hypertrophy
Villous atrophy
Lyphocytic infiltration