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Pharmacology > PAD > Flashcards

PAD Flashcards

1
Q

COX inhibitor

A

Aspirin

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2
Q

Aspirin MOA

A
  1. Nonselective irreversible COX inhibitor

2. Reduces platelet production of TXA2

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3
Q

Aspirin PK

A
  1. Antithrombotic (blocks TXA2)@ low dose (81-325 mg)

2. IRREVERSIBLE, 7-10 day lifespan

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4
Q

Aspirin side effects

A

GI upset and/or bleeding

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5
Q

Aspirin contraindications

A
  1. Active bleeding
  2. Hemophilia
  3. Thrombocytopenia
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6
Q

Dipyridamole (Aggrenox) MOA

A
  1. Phosphodiesterase inhibitor

2. Platelet aggregation inhibitor

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7
Q

Dipyridamole (Aggrenox) clinical application

A

Combine with ASA

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8
Q

Dipyridamole (Aggrenox) side effects

A
  1. HA
  2. Hypotension
  3. Dizziness
  4. Angina
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9
Q

Dipyridamole (Aggrenox) contraindications

A
  1. Active bleeding

2. CAD

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10
Q

Cilostazol (pletal) contraindications

A

CHF patients

=decreased survival

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11
Q

Cilostazol (pletal) MOA

A
  1. PDE inhibitor
  2. Suppress platelet aggregation
  3. Direct arter vasodilator
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12
Q

Clopidogrel (Plavix) MOA

A

Inhibits binding of ADP to its platelet receptor= IRREVERSIBLE inhibition of platelets

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13
Q

Clopidogrel (Plavix) clinical application

A
  1. ACS
  2. Prevention of responses after stent/angiography
  3. Prevent arterial thrombosis
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14
Q

What was the first drug used for PAD?

A

Pentoxifylline (trental)

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15
Q

Pentoxifylline (trental) MOA

A

RBCs flexibility-allows for easier flow through narrowed vessels

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16
Q

What drug do we not use anymore and why?

A

Ticlopidine- Causes leukopenia (low WBCs)

Pharmacology (9 decks)

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