pack 2

Question 1

What is a glycoprotein?

Answer 1

Sugar + protein

Question 2

Where does N-linked glycosylation take place?

Answer 2

Select asparagine in rER

(N in er bc N is before O in alphabet) (bc you sparing engine)

Question 3

Where does O-linked glycosylation take place?

Answer 3

In golgi on serine and theronine

(to show serine) (bc it is a theory that you have that might work)

Question 4

What is the sugar that is added to both O and N glycosylation

Answer 4

O: N-acetylgalactosamine
(bc women are lactose intolrent)

N: N-acytelglucosamine

Question 5

Does N&O glycosylation happen before or after folding?

Answer 5

N: before

O: after

Question 6

What process in collagen modification requires vitamin C?

Answer 6

Hydroxylation

(bc you get hydrated when you drink vitamin C)

Question 7

What happens when there is a problem in forming the triple helix in glycosylation?

Answer 7

osteogensis imperfecta

(the triple helix looks like candy which contain “glycogen”)

(if that candy is bad “expired” it will cause further bone problems)

Question 8

What enzyme does the cross linking?

Answer 8

lysyl oxidase

(Ly and Ly are linked by s
and oxygen is linked to everything)

Question 9

What is the disease caused by problems with cross-linking?

Answer 9

meneks disease

Question 10

What does lysyl oxidase require?

Answer 10

Copper

(bc the chain linking the ly which is made of copper oxidizes easily)