pack 1 Flashcards
What do free ribosomes synthesize?
Proteins that stay inside the cytoplasm
What do ribosomes bound to the rER synthesize?
Proteins that leave the cell and go to the cell membrane (bc they leave their house and they go to the ER)
Where does translation always start?
On free ribosomes
What is the endomembrane system for?
Anything going inside, outside or to the membrane
What are the components of the
endomembrane system?
RER, golgi apparatus, endosomes, secretory vesicles, and lysosomes
What are endosomes? What is their function?
They are: vesicles
Function: Transport from the golgi or inside or outside the cell
Where is the signal to send the proteins to the rER attached? Is it Hydrophobic or hydrophilic?
Attached: At N terminus (start)
Hydrophobic (bc it wants to get as far away from the water (ECF) as it can so it goes to the ER )
How does the taking the protein to the rER take place?
Translation starts in free ribosome
Signal recognition particle binds to signal
SRP stops translation
SRP takes the protein
SRP binds to SRP receptor on the ER
Both hydrolize GTP which causes the SRP to deattach from the protein and causes the
Transcolon channel to open and the ribosome to get pushed in
As the protein enters the organelle, the signal is cleaved by signal peptidase
Translation is resumed in the ER
What is translocon?
a channel that opens from hydrolization of GTP from the SRP complex to let ribosome in
What is signal peptidase?
Removes the signal from the protein
