P2Y12 Inhibitors Drug Info

Question 1

P2Y12 inhibitor that is reversible

Answer 1

Ticagrelor

Question 2

Oral P2Y12 inhibitors with the quickest onset of action (2)

Answer 2

Ticagrelor, Prasugrel

Question 3

Primary metabolism pathway for Ticagrelor

Answer 3

3A4

Question 4

P2Y12 inhibitors that are prodrugs (2)

Answer 4

Clopidogrel, Prasugrel

Question 5

P2Y12 inhibitors that are irreversible

Answer 5

Clopidogrel, Prasugrel

Question 6

Clopidogrel and Prasugrel bind at what receptor

Answer 6

ADP-binding

Question 7

Absolute contraindication for prasugrel

Answer 7

history of stroke/TIA

Question 8

Absolute contraindication for ticagrelor

Answer 8

history of cerebral bleed and severe liver disease

Question 9

What is the maintenance dose of Clopidogrel?

Answer 9

75mg daily

Question 10

Clopidogrel is metabolized by

Answer 10

a 2-step process involving 2C19

Question 11

When should you discontinue clopidogrel before surgery?

Answer 11

5 days before

Question 12

When should you discontinue prasugrel before surgery?

Answer 12

7 days before

Question 13

DAPT Duration after ACS

Answer 13

12 months

Question 14

DAPT duration after bare metal stent in stable ischemic heart disease

Answer 14

1 month

Question 15

DAPT duration after drug eluting stent in stable ischemic heart disease

Answer 15

3 months

Question 16

Clopidogrel loading dose

Answer 16

300-600 mg

Question 17

Ticagrelor loading dose

Answer 17

180 mg

Question 18

Prasugrel loading dose

Answer 18

60 mg

Question 19

Ticagrelor maintenance dose

Answer 19

90 mg twice daily

Question 20

Prasugrel maintenance dose

Answer 20

10 mg daily

Question 21

Prasugrel relative contraindications

Answer 21

< 60 kg, > 75 years of age