DI Argatroban

Question 1

Mechanism of Action of Argatroban

Answer 1

Direct thrombin inhibitor

Question 2

route of administration of Argatroban

Answer 2

continuous IV infusion

Question 3

half life of Argatroban

Answer 3

39-51 minutes

Question 4

Renal adjustments for Argatroban

Answer 4

approx. 15 % renal infusion, will likely need lower infusion rates. Not dialyzable

Question 5

Monitoring of Argatroban

Answer 5

1. aPTT 1.5-3x ULN

2. Monitor hemoglobin, hematocrit, platelets

Question 6

Clinical pearls of Argatroban

Answer 6

1. approx. 85% hepatobiliary elimination.

2. Will elevate INR