(P) Hemolytic Disease of the newborn part 1 Flashcards
Most important red cell antigen after A and B antigens in blood banking
D antigen
What is the other name for the hemolytic disease of the newborn
erythroblastosis fetalis
It is termed as erythroblastosis fetalis due to the
presence of ______
erythrolasts
T or F
A person with Rh negative blood can develop Rh antigens if he / she receives blood from a person with Rh positive blood
F (develop Rh ANTIBODIES)
T or F
A person with Rh positive blood can receive blood from a person with Rh negative blood without any problems
T
A condition in which the fetus or neonate’s red blood cell
are destroyed by IgG antibodies produced by the
mother.
HEMOLYTIC DISEASE OF THE NEWBORN
Definition of terms
breaking down of RBC
hemolytic
Definition of terms
The making of immature red blood cells resulting to the preence of erythroblasts in the blood
erythroblastosis
Definition of terms
refers to the fetus
fetalis
True for the causes of HDFN except:
a. Rh incompatibility
b. ABO
c. other system antibodies incompatibility
d. Rh positive mother, Rh negative baby
e. none of the above
d
A. Rh-HDN
B. ABO-HDN
- rare, declining, severe, clinically significant
- more common, mild, subclinical
- A
- B
other causes of HDN except
a. Anti-c (hr’)
b. Anti-E (rh’’)
c. IgM
d. Anti-Lea, Anti-Leb
e. Anti-P1, Anti-M, and Anti-N
c
familiarize the factors of HDN
- pregnancy
- factors affecting immunization
- immune response
- antigenic exposure
Factors of HDN
required for HDN to occur, as it is vital for antigenic exposure leading to HDN
Pregnancy
types of immune response
a. Non-responders
b. hyper-responders
- increases the titer of Anti-D or IgM
- Indifferent to antigenic stimulation
- B
- A
In hyper-responders, what is the product of the increase in titer of anti-D?
multiple antibody formation
Rh negative individual exposed to one unit of Rh-positive blood are ______% immunized
50%
Rh negative women with Rh positive fetus are ___%
immunized
10
____mL is needed in immunization to stimulate a response and create
antibodies in the process of stimulation
0.5mL
- Occurs when the volume of fetal red cells is insufficient.
- This occurs in primary immunization, and within the
secondary immunization is the rapid production of
antibody.
ANAMNESTIC RESPONSE
which pregnancy is of higher risk for Rh-HDN?
a. first
b. second
c. third
d. fourth
b
Rh incompatibility greatly affects a person’s quality of life and give rise to problems during pregnancy
a. first statement is true, second is false
b. second statement is true, first is false
c. both statements are true
d. neither statements are true
b
a. first pregnancy
b. second pregnancy
- antibodies are produced due
to the exposure of the maternal blood to the neonate’s blood - In the ___________ antibodies produced from
the x pregnancy attacks the fetus with Rh positive
blood - It is still considered safe but the mother who is RhD-
- a
- b
- a
what are the symptoms in mild cases of HDN
mild anemia and jaundice