Ozempic

Question 1

Key points

Answer 1

Co-morbidities = diseases that hang with each other.
Exercise is medicine because we can reduce weight with exercise and with medicine, but it is hard to do and not common.
Bariatric surgery is invasive and risky.
Prescriptions have increased.
Wegovy can be prescribed for weight management.
Know side effects associated with semaglutides.

Question 2

Bariatric Surgery

Answer 2

Put band around the stomach to shrink the volume of it.
Bypass = bypass esophagus right to small intestine to decrease how much you consume at a time.
Sleeve gastrectomy = put a sleeve around the stomach and squeeze it so it can’t be as big.

Question 3

GLP-1 Mechanism of Action

Answer 3

GLP-1 released in intestine…
-increases satiety signal
-increase insulin and decrease glucagon
-decrease gastric emptying (slows it down)
Short lived in humans because it is metabolized quickly by the body

Question 4

What does Ozempic do?

Answer 4

Semaglutide mimics GLP-1:
-amplified and sustained hormonal response
-metabolized less quickly than natural GLP-1
-allows for 1 shot per week

Question 5

Semaglutide vs Placebo Results

Answer 5

Increase insulin and suppresses glucagon.
Delays gastric emptying (decrease glycemic load).
Decrease appetite and fewer cravings.
Weight loss targeted fat and not lean mass.
Reduced LDL cholesterol and triglycerides.

Question 6

Cost

Answer 6

~250/week without insurance

Question 7

Weight Watchers All-In

Answer 7

Buys sequence, a telehealth subscription service that connects patients and doctors who can prescribe weight loss and diabetes drugs.

Question 8

Risks of Ozempic

Answer 8

Untimely deaths.
Pancreatitis.

Question 9

Unintended Consequences of Ozempic

Answer 9

Impacting access to Ozempic for people with Type II Diabetes because can’t get it if you need it.
Ontario limits supply to type II diabetes.