Oxygenation Physiology Flashcards
V/Q mismatch definition
Ventilation / Cardiac output mismatch
Perfusion equation
DO2 = Q x CaO2 Perfusion equals cardiac output x content of arterial oxygen
Process of glycolysis
Glucose is converted into two pyruvate molecules
Total ATP production of Krebs cycle
38 ATP
Name the three stages of metabolism in order
Glycolysis, Citric acid cycle, Oxidative Phosphorylation
Name the three Ps of Hypocapnia
Pulse, Perfusion, pH
Formula for calculating MAP
(SBP + (2 x DBP)) / 3
Definition of PaO2
Partial pressure of arterial oxygen
Definition of PO2
Partial pressure of environmental oxygen
Definition of PAO2
Partial pressure of alveolar oxygen
Definition of SaO2
Saturation of arterial oxygen
Definition of SpO2
Saturation of bound hemoglobin
Definition of SvO2
Venous oxygen saturation (pulmonary artery catheter)
Definition of ScvO2
Central venous oxygen saturation (central line catheter = 5-8% higher than SvO2)
Definition of CaO2
Content of arterial oxygen
Definition of DO2
Delivery of oxygen
Carrying capacity of hemoglobin for oxygen
1.34 mL
Typical cardiac output for an adult
5L / min
Typical BSA for an adult
1.7 m2
Definition of Fick Formula
Cellular uptake of oxygen
List the four identifiable causes of hypoxia
Hypoxic, hypemic, stagnant, histotoxic
Relationship between EtCO2 and PaCO2
PaCO2 is higher by 2-3 points
Relationship between SpO2 and PaO2
SpO2 is higher by 30 points
Name of the effect that causes a rightward shift of the OHDC
Bohr effect
Factors that cause a rightward shift of the OHDC
Raised acid, raised CO2, raised temp, raised 2-3 DPG, raised PaO2
Define Haldane effect
Hemoglobin’s ability to offload oxygen is directly proportional to acid levels and concentration of CO2
Name of the effect that causes a leftward shift of the OHDC
Haldane effect
Factors the cause a leftward shift of the OHDC
Low temp, low acid, low 2-3 DPG, low PaO2
Relationship of SpO2 and PaO2 with a rightward shift of the OHDC
SpO2 decreases, PaO2 increases
Relationship of SpO2 and PaO2 with a leftward shift of the OHDC
SpO2 increases, PaO2 decreases