Oxygen Measurements + Oximetry Flashcards
Define Oxygen capacity
the max quantity of O2 which can combine with Hb in a unit volume of blood
Normal Hb levels for male:
160g/Litre
Normal Hb levels for female:
135g/Litre
How much can 1g of Hb combine with O2
1.34ml of O2
maximum amount body can carry
201ml/L
Explain Oxygen saturation
(SO2)
when O2 is fully saturated, 4 binding sites on HB all have O2 bound to them (100)%
normal O2 sat is 95-98%
Can be measured by an oximeter
What is SaO2 and SpO2
arterial oxygen saturation
peripheral oxygen saturation
Define oxygen content
is the total volume of oxygen carried by the blood
units ml per litre
Oxygen content equation
O content= o2 carried by Hb + O2 in solution
Calculate CaO2
(1.34xhb)x SaO2/100 +(0.225 xPaO2)
=201+3
=204ml of O2 per litre of blood
Factors affecting O2 content
- partial P of inspired O2
- efficiency of ventilation and gas exchange
- Hb level and affinity of Hb for O2
PaO2 (partial arterial pressure) determines o2 saturation of Haemoglobin
anemia:
The partial pressure of O2 is normal, low hemoglobin, has normal oxygen saturation, as sites that are available are saturated, just less sites for binding
Define hypoxia, hypoxemia and cyanosis
Hypoxemia- lack of O2 in the blood
Hypoxia- reduced O2 to the tissues
Cyanosis- blue coloration of skin and mucus membranes resulting from raised levels of deoxyhemoglobin caused by hypoxemia
Causes of Hypoxemia:
- Hypoventilation (not breathing efficiently): causes raised CO2 in the blood (hypercapnia)
- diffusion limitation: e.g., lung fibrosis, problem getting O2 across alveoli membrane, CO2 is more soluble
- Shunt: blood that has gone through the lungs, but has not been ventilated
- V/Q mismatch: Ventilation and perfusion,
diseases cause large mismatch causing so areas to not be ventilated, but still perfused, leading to hypoxemia
pH of blood:
7.35-7.45
Standard partial pressure of CO2
4.8-6.0 kPa