Oxygen Dissociation Curve Flashcards
1
Q
What does a ODC curve show
A
The relationship between hb, 02 and partial pressure
2
Q
What is partial pressure
A
Concentration of gas
3
Q
What happens at the beginning of an ODC curve
A
- Has a initially shallow gradient
- shape of the hb makes it difficult for the 1st 02 to bind
- this means the 02 conc is low as little 02 binds with hb
4
Q
Was happens in the middle of ODC curve
A
- the gradient steepens
- smaller increase in partial pressure of 02 when binds to 2nd
- positive cooperativity binding of 2nd 02 easier than 1st
5
Q
What happens at the end of an ODC curve
A
- Gradient of curve reduces and graph plateaus
- after hb bids to 3rd 02 binding to 4th 02 is harder
- this is due to probability of 02 findings an empty binding site
6
Q
What is allostery
A
- quaternary structure changing shape due to 02 attaching to fe2+
7
Q
What happens when quaternary Structure of hb changes shape
A
It exposes the 2nd haem group so 02 uptake is faster this is also know as the cooperative nature of 02 binding
8
Q
What does it mean when the ODC curve is further left
A
Greater affinity of hb for 02
9
Q
What does it mean when the ODC curve is further right
A
Lower the affinity of hb for 02
