oxazolidinones and fusidic acid

Question 1

what is the moa of oxazolidinones

Answer 1

they inhibit protein synthesis
by binding 23S of 50S thus preventing formation of 70S initiation complex thats imp for translation process

lindezolid is bacteriostatic against Enterococci and staphylcocci

and is bactericidal against streptococci

Question 2

whats something special about tedizolid

Answer 2

its inactive until its in vivo and dephospharlayted

its structure allows it for tighter binding to the ribosome thus higher potency

Question 3

antibacterial spec of oxazolidinones

Answer 3

1) Gram +ve cocci

Streptococci , staphylcocci (MRSA), enterococci (VRE)

2) Gram +VE rods

-L. monocytogenes , Bacillus , corynebacterium

3) M. tuberculosis

Question 4

indications of oxazolidinones

Answer 4

linezolid:

• empiric therapy or due to MRSA or VRE
• Bacteraemia
• pneumonia

-diabetic foot infection

-complicated UTI

-Skin and soft tissue infection (both drugs)

Question 5

indications of oxazolidinones

Answer 5

linezolid:

• empiric therapy or due to MRSA or VRE
• Bacteraemia
• pneumonia

-diabetic foot infection

-complicated UTI

-Skin and soft tissue infection (both drugs)

Question 6

AE of oxazolidinones

Answer 6

GI effects , headache , rash

anemia , leukopenia and thromocytopenia

Question 7

fusidic acid

Answer 7

natural antibitoic that has a steroidal structure doesnt posses any steroidal activity

merely has high penetration power due to steroidal nature

Question 8

FA mOA

Answer 8

It has bacteriostatic and bactericidal activity mainly against Gram +ve

inhibits protein synthesis by blocking aminoacyl-tRNA transfer to protein

Question 9

FA antibacterial spec

Answer 9

S. aureus

Gram +ve anaerobes
-C.diff , M. leparae

Streptococci are resistant

Question 10

indications of FA

Answer 10

Staphylococcal infections (not used as mono therpay but combined with other antistaph agents or else resistance occurs)

Skin and eye infections ( topical )