clindmycins

Question 1

Where is clindamycin derived form

Answer 1

semisynthetic derivative of lincmycin

OH at c7 is replaced with Cl and configuration at that carbon is inverted

Question 2

explain clindamycin MOA and how does it kill and what does it bind to

Answer 2

its bacteriostatic

binds to 50S ribosomes and affects protein synthesis

Question 3

what is clindamycin mot active towards

Answer 3

Gram positive aerobic and anaerobic bacteria

Question 4

Clindamycin antibacterial spec

Answer 4

1) Gram +ve cocci

-Streptococci (S. pyogenes , S. pneumonia , S. viridans

-Staphylcocci (MRSA)

2) Gram +ve rods

-B. anthracis and C. diphtheria

3) Anaerobes

• B. fragilis , C.perferingens , C. acne

Question 5

what bacteria are clindamycin not active against

Answer 5

not active against enterococci

not active against ANY aerobic Gram -ve rod:

-H.influnzae

-N. meningitidits

-M. pneumonia (Mycoplasma pneumonia)

Question 6

Indications of clindamycin

Answer 6

-Bone and joint infections (Osteomyelitis or septic arthritis) due to S.aures (MRSA)

-Intra-abdominal infections (peritonitis , abscess)

-DIABETIC FOOT INFECTION

-Gynecological infections ( endometritis , pelvic cellulitis) caused by SUSCEPTIBLE ANAEROBES

Skin and soft tissue infection like cellulitis and impetigo caused by S.aures , S.pyogenes and anaerobes

-Pneumonia, lung abscess and septicemia caused by S.aures , anaerobes , Streptococci

Question 7

AE of clindamycin

Answer 7

Antibitoic-associated colitis caused by C.diff

occasional impaired liver function and neutropenia

Nausea , diarrhea , rash and contact dermatitis (topical use)