Ovo/follico genese Flashcards

1
Q

qd se met en place act ovairienne

A

puberte

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2
Q

qd 2e division de meiose

A

fecondation

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3
Q

la fin de la division reductionnelle entraine la formation du premier globule polaire ?

A

oui (?? tut)

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4
Q

syno de foll de Graaf

A

prevovulatoire/mur

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5
Q

syno de foo preantraux

A

secondaire tres mur

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6
Q

ovaire a une double fonction exogene et endeogene gametgene

A

faux : exogene gametogene

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7
Q

quel noyau se deplace en periph

A

ovocyte 1

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8
Q

foll 2e : granulosa se met en place comment

A

via des jonctions gap

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9
Q

taille follicules 2e

A

80-180microns

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10
Q

ovaires ds cavite peritoneale ds une depression du pelvis ?

A

non ds depression du pevis et cavite peritoneale

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11
Q

autres lieux action des hormones ovariennes

A

peau, os, arteres

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12
Q

synonyme stade preovulatoire

A

involution

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13
Q

critere gamete de qilaite

A

fecondable et a loriigne du bon dvt embryonnaire

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14
Q

qd debute phase de croissance

A

NAISSANCE

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15
Q

ovogenese phenocontonu

A

non car 2 pahses de blocage

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16
Q

noyau de ovocyte visible en MET

A

non

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17
Q

apparence de ovocyte

A

peu differenciee

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18
Q

globule polaire : nb de chromo et signe de ?

A

maturaiton

n chromosomes

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19
Q

migration embryon 4e semaine

A

vers le mesentere posterieur (relie paroi abdo POST et organes dont l’intestin primitif)

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20
Q

origine des cell germinales

A

externe

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21
Q

etapes 4e semaine de dvt

A

diff / delimitation / dvt sys nerveux / cordon ombi

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22
Q

qui donne naissance aux ovogonies

A

cell germinales de la 2e poussee embyronaire

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23
Q

nom ovocyte au stade 1

A

stade cdictie

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24
Q

qd ovogonies se trans en ovocytes 1

A

apres synthese adn (avt chaque division cell)

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25
Q

quelles competences ovocytaires s’acquierent qd

A
  1. meiose : avt cellle du dvt

2. dvt : apres LH pic

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26
Q

ovocyte 1 synthese de quelles prots ex

A

ZP123

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27
Q

nature Zp123

A

glycoprot - zone pellucide

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28
Q

fecondation in vitro

A
  • cx cumulo-ovo1 folll aanttrum
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29
Q

pb in vitro

A

maturation cytoplamqiue et acquisi dvt –.> tx implantation 2x plus bas

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30
Q

role des granules corticaux

A

vesicules de golgi (SOUS MP) qui bloquent polyspemie)

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31
Q

obs de ovocyte immature possible

A

MET oui

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32
Q

qd ovo1 acheve 1e division meio

A

34h apres LH il va jusque telophase1

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33
Q

talle esp perivtiellin ovo2

A

tres reduit a ce stade

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34
Q

qd ovo2 expulse

A

qd en metaphse II

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35
Q

pq meoise 2 ne continue pas et pq continu si fecon

A

corona radiatia envoie message negatifs - contact du sperma aveczone pellucide

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36
Q

MET : on obs d’abord le noyau ovo feou expulsion globule polaire

A

expulsion du globule polaire

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37
Q

diff MET et MET colorisee

A

esp preivitel&raquo_space;

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38
Q

1er stade de dvt

A

2 pronyaux 2 globules polaires

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39
Q

qte ADN et chromoes ovo1,2,f

A

1 : 46chr4q
2. 23chr 2q
f : 23ch1q

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40
Q

def tissus a potentilite gametiques

A
coretx ovaire (partie periph de ovaire)
puple testi
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41
Q

gametes ds ovaire

A

presents que qq heures avant l’ovulation

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42
Q

ovo1 ou 2 ds les follicules

A

ovo1

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43
Q

debut active follicu

A

7e mois

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44
Q

cb ovulations ds une vie

A

300-400

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45
Q

evo nb de foll

A

7M - 1M - 0.3 - 0.001

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46
Q

decroissance fertilte

A

35-37

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47
Q

def syncitium

A

GAP foll2

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48
Q

diametres foll antraux

A

tres variables (180microns a pls mm)

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49
Q

quelle phase ovo plus central

A

foll antruax

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50
Q

qd part cumulus oophorus

A

ovulation

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51
Q

taille ovocyte 1 de Graaf

A

120-150microns

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52
Q

tunique theque interne de graaf

A

concentrique

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53
Q

taille de graaf

A

2cm

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54
Q

action pic de LH sur cumulus oophorus

A

dissociation de substance mucoides –> ‘petit nuage’ 3-4mm

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55
Q

dissociation cx cumu-ovo

A

cumulus secretent mucopolysaccharides - ici disso –> lib de cavite antrale

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56
Q

qd rupture vesicule germinale

A

qd lib du globule polaire a j14

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57
Q

maturation du cytopplasme en // de ovulation

A

oui

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58
Q

desxcr foll

A

bombe a la surface de l’ovaire

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59
Q

secretion hormonale signe direct de ovulation

A

non indirect

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60
Q

hormones du corps jaune

A

E, PG (caliente), androgenes

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61
Q

atresie

A

cyto granuleuxet … nnyoau se retrceit

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62
Q

cb de % foll atresie

A

95%

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63
Q

qui secrete hormones steroides ds le corpsjuane

A

granulosa

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64
Q

atresie foll

A

ovo en 1er (gal) : cyto granuelux, inclusions lipidiques, noyause pycnose

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65
Q

eg hormone polypept

A

inhibine

66
Q

folliculogenese tjs cyclique

A

continue mais cyclique que les 15derniers ours

67
Q

diff esp ont des phases de quiescence et croisance diff

A

oui

68
Q

cb de foll a la puberte

A

300 000

69
Q

methodes explo de folli

A

forttis vaignal - bio de ENDOMETRE - echtomographie pelvienne - courbe ther - obs qualite du corps jaune

70
Q

but AMP

A

supprimer selection et dc amener pls foll a maturite

71
Q

paracrine/autocrine diff de endoctrine

A

OUI

72
Q

liberation de LH 36h avt ovulation

A

non 34h avt

73
Q

croissane folli : j foll antral precoce ?

A

vrau

74
Q

cb de foll primordiaux a la naissance`

A

1million

75
Q

maturation ovocytaire : etapes necessaires a rendre ovo fecondable ?

A

oui

76
Q

ovocyte 1 est une gamete

A

non car pas mature

77
Q

ovule existe

A

stade fictif

78
Q

def ovule

A

ovocyte + 2ou3 globules polaires

79
Q

ovocyte II (=mature) appdiff

A

peu

80
Q

in vitro : bcp de critres quliate spour ovocyte

A

non juste naissance de l’enfant

81
Q

ovocyte doit juste assurer le debut du dvt embry ?

A

et decondenser ADN du sperma et fusion avec sperm

82
Q

qd colonisation des cretes geniales

A

fin 4e semaine

83
Q

presence d’un cordon ombilical a la 4e semaie

A

oui

84
Q

ou migrent les cell germina les a la 4e semaine

A

mesentere posteiruer

85
Q

ovogonies :

A

2e!!!

86
Q

ovogonies : mitoses en continue ds la vie

A

non juste du4e au 7emoi

87
Q

stade dyctie

A

= blocage diplotene de meoise 1

88
Q

vesicule germinative : ovo1 ou 2

A

ovo1

89
Q

ovo1 : noyau3x4 son volume

A

non ca cest la cell noyau que x2

90
Q

quel facteur influence 2 copetences ovo(meoise et comeptence au dvt)

A

taille dpt

91
Q

acquisition competence meoitque et dvt : exprimees en meme temps

A

oui

92
Q

maturation ovo finake : rapide ou lente

A

TRES rapide

93
Q

croissance ovo : ARNx100

A

non x300 !

94
Q

croissance ovo : synthese des prot du cycle cell

A

oui

95
Q

3 modifs special cyti phase de croissance

A

mitochondire&raquo_space; –> qualite de ovoyte
granules corticaux (// acrosome)
ZP1-2-3 –> zone pellucide

96
Q

membrane ovo a des MV qui bombe ds esp periviteekin ?

A

oui

97
Q

double maturation ovocytaire >

A

non triple : noyau cytoplasme membrane

98
Q

ovo II cb de chromosomes et de q adn

A

23chromoses mais 2q adn (‘mitose1’)

99
Q

ovocyte ovule = ovo mature

A

non bloque en metaphase de meoise2

100
Q

qd esp perivitellin reduit

A

apres fin de meoise1

101
Q

diff obs zygote MET et MET colorise

A

colorise : esp perivitellin + important

102
Q

obs possible microoptique INVERSEE du zygote

A

oui

103
Q

pq cortex ovarien pas tissu gametique

A

car n=46chromosones

gamte = 23 chromosomes

104
Q

plusieurs couches de foll primordiaux sous albuginee

A

oui

105
Q

age debut diminution de fertilite

A

35-37

106
Q

granulosa vascularise

A

non

107
Q

nature zone pellu

A

membrane hyaline fine

108
Q

existe intermediaires fooll primaire - primordial

A

oui cell cubes et aplaties

109
Q

a aprtir de q stade zone pellu visible

A

stade 3 = secondaire = preantral

110
Q

Theque = TC

A

oui

111
Q

daimetre de q foll tTRE variable

A

foll antraux-tertaires

112
Q

theque int a des cell epitheloide

A

oui qui secrente des des steroides

113
Q

q stade foll commence a etre sensible aux gonadotrophins

A

foll tertaire antral

114
Q

q stade foll a PLS cavites

A

foll natral –> plusieurs cavites font fusioner

115
Q

cell de la granulose : toutes le mem nom

A

non murale - corona radiata

116
Q

foll de graaf : ‘kyste”

A

oui

117
Q

ovocyte 2 ds les foll

A

NON que 1

118
Q

theque ext : conjonctivo fibreuse

A

oui car ext donc resis donc fibreu

119
Q

ct ovulation

A

Lh–> mucoide –> disso cumulus –> ovocyte 1 devient ovo2

120
Q

def stricte ovulatioj = expulsion de ovule

A

ET du cx cumulo ovocytaire

121
Q

hormone : signe de fecondation

A

oui mais INDIRECT

122
Q

def processus involutif

A

atresie foll

123
Q

corps jaune a du cholestero

A

oui car choles = precueurseur des steroides

124
Q

nature des enclaves ds ovo atresie

A

lipidque

125
Q

ovulation : rupture a quel niveau

A

stigma

126
Q

stigma ou

A

paroi folli

127
Q

ovulation : lib de la cavite antrale

A

oui

128
Q

phase de croissance dpt des gonadotrophines

A

non car avt adolesence

129
Q

foll quiescents = foll primordiaux

A

oui

130
Q

syndrome de tuerner

A

acceleration de la perte foll

131
Q

qd debut cycle ovarien

A

J1 regeles

132
Q

progesterone secrette de J1 a J14

A

non a partir de j14 phase luteale

133
Q

croissance foll de base : j- a quel stade

A

croisssance fol de base = j- stade antral precoce

134
Q

entre naissance et adole : ovaires fonctionnent

A

oui –> croissance de base des foll

les ovaires fonctionnent mais l’act ovarienne est mise en place a ladolescence

135
Q

taille terminale du foll en phase luteale

A

non car phase luteale on a deja un corps juane

136
Q

hypophyse ou hypothalamus = gland qui pend a la base du cerveau

A

hypophyse

137
Q

pic de FSH a j14

A

oui

138
Q

FSH agit sur granulo ou cell theque int

A

granulo

139
Q

LH agit ou

A

cell theque interne

140
Q

presence de progesterone en phase oestro

A

quasi pas

141
Q

variation E2

A

max J12 puis baisse a J14 puis remontee puis baisse j22

142
Q

Progesterone fin de cycle : bcp ou peu

A

decroit

143
Q

quelle cell secrete oestroegene et androgens

A

andorgeens : theque int (//Leydig)

oestroge : granulo

144
Q

transfomration des andorgenes en oestrogene par qui

A

cell de la granulosa

145
Q

ct ovulation

A

granulosa devient sensiblep a la Lh –> + andorgenes => + oestro => retrocontrole positif => pic de FSH et Lh

146
Q

coprs juane secretent E2

A

oui car mini pic

147
Q

inhibine pdt tout le cycle

A

oui => secretee par foll ET corpsnjane

148
Q

recrutement : cb de foll et pq recurte

A

sensibles au gonadotrophines

10-20 foll

149
Q

qd selection

A

chute FSH le 7e jour

150
Q

cell de grnualosa ac recepteurs a LH indisp a ovulation

A

oui

151
Q

a quels moments regulation paraetauto

A

initiation de la croissance foll - croissance foll debase et dominance

152
Q

relation de proprtionalite reserve ovarienne et foll en croissance

A

oui

153
Q

signes indirect de la reserve ov

A

mesurer nb de petits folll a antrum - doser AMH(car secretee par les foll en croissance)

154
Q

debut menopause = 0 foll

A

non <1000 mais => ovaires plus sensibles aux gonadotrophines

155
Q

diagostique ovualtion : signes directs possibles

A

non indirect

156
Q

progesterone : hyper ou hypothermisante

A

hyper

157
Q

que permet observation du frottis vaginal

A

si phase oestro ou proges

158
Q

granulosa differenceiee grace a ovocyte

A

oui

159
Q

tous les folll voues a atresie

A

oui

160
Q

pic de LH a J14

A

non : 34h avt ovulation => il faut du temps pour que foll murisse