Overview and Carbonic Anhydrase Inhibitors

Question 1

Loop diuretics
Thiazide dirutetics
Na channel blockers

Answer 1

Furosemide

Chlorthalidone and hydrochlorothiazide

Amiloride, eperenone, spironolactone, traimeterene

Question 2

ACEI

ATrecep blocks

Direct renin inhibt

Answer 2

Lisinopril

Losartan

Aliskerin

Question 3

CAI site and mech

Answer 3

Inhibition of proximal tubule CA

This prevents conversion of H2O and CO2 to H2CO3

Question 4

CAI effects

Answer 4

Modest diuresis and loss of HCO# and Na

Renal compensatory mechs imit the diuretic and Na loss effect

Question 5

CAI therpaeutic use

Answer 5

Glaucoma and altitiude sickness

Question 6

CA toxocity

Answer 6

Metabolic acidosois due to loss of bicarb

Sedation and paresthesias

Similar to sulfonamides so maybe allergic reactions

Question 7

CAI drug interactions

Answer 7

Decreases elimination of weak bases due to increase in urinary pH

Elevated pH - weak bases no charged and more likely to be reabsorbed