Drugs that Modify the Renin-Angiotensin-Aldosterone Axis

Question 1

Angiotensin receptor antagonists

Answer 1

AT2 interacts with both the AT1 and AT2 receptor…we are interested in the AT1 receptor…this is where the ARBs block

Question 2

Indications for ACEIs and ARBs

Answer 2

Heart fiailure and HTN

Question 3

Cuations of ACEIs and ARBs

Answer 3

Pregnancy

Question 4

Side effects of ACEIs

Answer 4

Persistant cough…blockage of bradykinin degradation can lead to cough

Question 5

Side effects of both ACEIs and AT1 receptor antagonist

Answer 5

Hyperkalemia due to inhibition of aldosterone secretion

Angiodedema
Loss of taste
Hypotension

Question 6

Aliskerin

Answer 6

Binds to active site of renin, therefore levels of AT2 are decreased

Can be used alone or with others for HTN

Question 7

Aliskerin contraindciations

Answer 7

Don’t combine with ARBs or ACEIs in diabetic patients