overdoses

Question 1

NAC can cause what type of side effect reaction if infused to quickly

Answer 1

Acetylcysteine commonly causes an anaphylactoid reaction (non-IgE mediated mast cell release).

Question 2

how do you treat a acetylcysteine anaphylactoid reaction

Answer 2

stop the infusion and restart at a slower rate

Question 3

liver transplantation criteria post paracetamol ingestion

Answer 3

Arterial pH < 7.3, 24 hours after ingestion

or all of the following:
prothrombin time > 100 seconds
creatinine > 300 µmol/l
grade III or IV encephalopathy

Question 4

aspirin overdose what do we see on ABG

Answer 4

Initial respiratory alkalosis due to stimulation of the central respiratory centre causing increased respiratory effort. Following this, a metabolic acidosis develops along side the respiratory alkalosis. This is due to the direct effect of the metabolite salicylic acid.

Question 5

how does IV bicarb work on aspirin

Answer 5

enahnces elimination in the urine