Ovarian Tumors - Surface Epithelial Tumors Flashcards
What are the three cell types in the ovary?
Surface epithelium, germ cells, sex cord stroma
What is the most common type of ovarian tumor? Where is it derived from?
Surface Epithelial tumor (70% of cases). Derived from coelomic epithelium that lines the ovary.
What is the embryological origin of the epithelial lining of the fallopian tubes , endometrium and endocervix?
Coelomic Epithelium
What are the two most common types of surface epithelial tumors? What characteristic do they share?
Serous tumors which are full of watery fluid and mucinous tumors which are full of mucus like fluid. oth are cystic
What are cystadenomas composed of? Which age group do they arise in?
Composed of single cyst with a simple flat lining. Most commonly arise in premenopausal women (30 - 40 years old)
What are cystadenocarcinomas composed of? Which age group do they arise in?
Composed of complex cysts with a thick, shaggy lining. Most commonly arise in postmenopausal women (60 - 70 years old)
What are cystadenocarcinomas composed of? Which age group do they arise in?
Composed of complex cysts with a thick, shaggy lining. Most commonly arise in postmenopausal women (60 - 70 years old)
BRCA1 mutation carriers have an increased risk for ____ carcinoma of which two structures? What procedure do they have to reduce their risk?
Serous carcinoma of the ovary and fallopian tube. They have a prophylactic salpingo-oophorectomy along with a prophylactic mastectomy due to increased risk for breast cancer.
Are Brenner tumors benign? What kind of epithelium are they composed of?
Composed of bladder like epithelium and are usually benign. Benign.
What are endometriod tumors composed of? Are they benign? Where do they arise from? What type of carcinoma are they associated with?
Composed of endometrial like glands and are usually malignant. May arise from endometriosis. 15% associated with independent endometrial carcinoma.
What are endometriod tumors composed of? Are they benign? Where do they arise from? What type of carcinoma are they associated with?
Composed of endometrial like glands and are usually malignant. May arise from endometriosis. 15% associated with independent endometrial carcinoma.
When and with what symptoms do surface tumors present? What is their prognosis and how do they spread?
Clinically present late with vague abdominal symptoms (pain and fullness) or signs of compression (urinary frequency). Poor prognosis. Epithelial carcinomas tend to spread locally, especially to the peritoneum.
What is a useful marker to monitor treatment response and screen for surface epithelial tumors?
CA-125
