Ovarian Tumors (Pathoma)

Question 1

What are the 3 cell types of the ovary?

Answer 1

1. Surface epithelium
2. Germ cells
3. Sex cord stroma

Question 2

What is the most common type of ovarian tumor?

Answer 2

surface epithelial tumors

Question 3

What is the embryologic origin of the ovary

Answer 3

1. Derives from coelomic epithelium that lines the ovary
2. Coelomic epithelium embryologically produces the epithelial lining of the fallopian tube (serous cells), endometrium, and endocervix (mucinous cells)

Question 4

What are the most two common sub-types of surface epithelial tumors?

Answer 4

Serous and mucinous

Question 5

Serous tumors are full of

Answer 5

water fluid

Question 6

Mucinous tumors are full of

Answer 6

mucus-like fluid

Question 7

Mucinous and serous tumors can be

Answer 7

benign, borderline, or malignant

Question 8

What are some of the characteristics of Benign tumors (cystadenomas)

Answer 8

1. Composed of a single cyst with a simple, flat lining

2. Most commonly arise in premenopausal women (30-40 yrs old)

Question 9

Malignant tumors (cystadenocarcinomas) are composed of

Answer 9

complex cysts with a thick, shaggy lining, most commonly arise in postmenopausal women (60 - 70)

Question 10

Borderlines tumors have features in between

Answer 10

benign and malignant tumors

better prognosis than clearly malignant tumors, but still carry metastatic potential

Question 11

BRCA1 mutation carriers have

Answer 11

an increased risk for serous carcinoma of the ovary and fallopian tube

Question 12

BRCA1 carriers often

Answer 12

elect to have a prophylactic salpingo-oophorectomy (along with prophylactic mastectomy due to the increased risk for breast cancer)

Question 13

What are the less common subtypes of surface epithelial tumors?

Answer 13

1. Endometrioid

2. Brenner tumor